HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bdf 9148
BDF 9148 · 4-[3-[[1-(Diphenylmethyl)azetidin-3-yl]oxy]-2-hydroxypropoxy]-1H-indole-2-carbonitrile
Identifiers & Physical Properties
| CAS No. | 120838-62-2 |
|---|---|
| Molecular formula | C28H27N3O3 |
| Average molar mass | 453.5 g/mol |
| Monoisotopic mass | 453.20524173 g/mol |
| SMILES | N#Cc1cc2c(OCC(O)COC3CN(C(c4ccccc4)c4ccccc4)C3)cccc2[nH]1 |
| InChIKey | KQQFGABYYXEKDM-UHFFFAOYSA-N |
| PubChem CID | 123765 |
| DTXSID | DTXSID50923578 |
Chemical & Physical Properties
| XLogP | 4.4 |
|---|---|
| Topological polar surface area | 81.5 |
| Hydrogen bond donors | 2 |
| Hydrogen bond acceptors | 5 |
| Rotatable bonds | 9 |
| Heavy atoms | 34 |
| Formal charge | 0 |
| Complexity | 660 |
Applications & Uses
Description
BDF 9148 is a Na(+)-channel modulator as well as a congener of DPI 201-106, and was found to increase the contractile force of guinea-pig atria and papillary muscles.
Uses
BDF 9148 is a sodium-channel activator with antiarrhythmic properties that produces a significant CAMP-independent positive inotropic effect in left ventricular myocardium from failing hearts. BDF 9148 is promising for research of myocardial failure[1].