HuagongsheHuagongshe Chemistry Print Report · For research reference only
11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one
11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one · 11β,17β-Dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-trien-3-one · (11β,17β)-11,17-Dihydroxy-6-methyl-17-(1-propynyl)-androsta-1,4,6-trien-3-one · Androsta-1,4,6-trien-3-one, 11,17-dihydroxy-6-methyl-17-(1-propynyl)-, (11β,17β)-
Identifiers & Physical Properties
| CAS No. | 74915-64-3 |
|---|---|
| Molecular formula | C23H28O3 |
| Average molar mass | 352.474 g/mol |
| Monoisotopic mass | 352.20384476 g/mol |
| SMILES | CC#C[C@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C |
| InChIKey | UFZKDKHLKHEFGA-ZFTCBNFESA-N |
| PubChem CID | 123790 |
| DTXSID | DTXSID101027141 |
Chemical & Physical Properties
| Boiling point | 533.2±50.0 °C(Predicted) |
|---|---|
| Density | 1.21±0.1 g/cm3(Predicted) |
| Storage conditions | 2-8°C |
| Solubility | DMSO: 33 mg/mL, soluble |
| Physical state | solid |
| pKa (acidity coefficient) | 12.82±0.70(Predicted) |
| FDA UNII | VH397CN9SV |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
| Water hazard class (WGK) | 1 |
Safety & Regulations
| Water hazard class (WGK) | 1 |
|---|---|
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Applications & Uses
Uses
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2]. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.