Completing data — refresh the page later to see the latest
Basic information
- CAS
53342-16-8- Standard SMILES
CC1(C)NC(=O)[C@H](CCCCCC(=O)[C@@H]2CO2)NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O- InChIKey
SGYJGGKDGBXCNY-QXUYBEEESA-N- Molecular formula
- C28H38N4O6
- Average molar mass
- 526.634 g/mol
- Monoisotopic mass
- 526.27913494
Names & identifiers
- Preferred name
- 9-Benzyl-1,4,7-trihydroxy-6,6-dimethyl-3-[6-(oxiran-2-yl)-6-oxohexyl]-6,9,12,13,14,14a-hexahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-10(3H)-one
- IUPAC
- (3S,9S,14aR)-9-Benzyl-1,4,7-trihydroxy-6,6-dimethyl-3-{6-[(2S)-oxiran-2-yl]-6-oxohexyl}-6,9,12,13,14,14a-hexahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-10(3H)-one
- English name
- CHLAMYDOCIN
- Molecular formula
- C28H38N4O6
- Molecular weight
- 526.63
Names & synonyms
SL-3440CHLAMYDOCINAntibiotic SL-34402-Methylcyclo[Ala-L-Phe-D-Pro-6-[(S)-2-oxo-2-oxiranylethyl]-L-Nle-]Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl]Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl]
Database identifiers
- CAS
53342-16-8- PubChem CID
- 124134
- DTXSID
DTXSID60967968- ChEMBL
CHEMBL6092022- Nikkaji
- J358.671E
Properties
Physicochemical properties
- Boiling point
- 861.8 · 861.8±65.0 °C(Predicted)
- Density
- 1.27 · 1.27±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- DMSO: soluble; Ethanol: soluble; Methanol: soluble
- form
- A solid
- pka
- 13.36 · 13.36±0.70(Predicted)
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302+H312+H332-H315-H319-H335
- Precautionary statements
- 260 · P260-P280-P312
- HS Code
- 29419000 · 29419000
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- hs_code
- 29419000
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302+H312+H332-H315-H319-H335
- Precautionary statements
- P260-P280-P312
Chemistry & industry
Applications
DescriptionChlamydocin is a histone deacetylase (HDAC) inhibitor that was originally isolated from D. chlamydosporia and has anticancer properties. It is selective for HDAC1 over HDAC6 (IC50 = 0.15 and 1,100 nM, respectively). Chlamydocin increases acetylation of histone H3 and histone H4 in A2780 cells when used at concentrations ranging from 1 to 1,000 nM. It inhibits growth of A2780, Malme-3M, MCF-7, HT-29, and HeLa cancer cells (IC50s = 0.36, 45, 5.3, 4.3, and 14 nM, respectively). Chlamydocin increases lifespan by 10% in a P185 mouse allograft model when administered at doses ranging from 20 to 160 mg/kg.
UsesChlamydocin is a cyclic tetrapeptide and an irreversible histone deacetylase (HDAC) inhibitor.
Suppliers13 total
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海一研生物科技有限公司021-69985186 13611928337 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
杭州洁汉化工有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…