Pyrimido(5,4-d)pyrimidine, ethanol deriv.
Basic information
- CAS
54093-30-0- Standard SMILES
CCN(CC)c1nc(N(CCO)CCOC)nc2c(N(CC)CC)nc(N(CCO)CCOC)nc12- InChIKey
ROFXYKJBKWRUBS-UHFFFAOYSA-N- Molecular formula
- C24H44N8O4
- Average molar mass
- 508.7 g/mol
- Monoisotopic mass
- 508.34855191
Overview
has central hypertensive properties; structure
Names & identifiers
- Preferred name
- Pyrimido(5,4-d)pyrimidine, ethanol deriv.
- IUPAC
- 2-[[4,8-bis(diethylamino)-2-[2-hydroxyethyl(2-methoxyethyl)amino]pyrimido[5,4-d]pyrimidin-6-yl]-(2-methoxyethyl)amino]ethanol
- English name
- RA 642
- Molecular formula
- C24H44N8O4
- Molecular weight
- 508.66
Names & synonyms
RA 64254093-30-0RA-642DTXSID902024302,2'-((4,8-Bis(diethylamino)pyrimido(5,4-d)pyrimidine-2,6-diyl)bis((2-methoxyethyl)imino))bisethanolRefChem:930379DTXCID90124921Pyrimido(5,4-d)pyrimidine, ethanol deriv.RA6422-[[4,8-bis(diethylamino)-2-[2-hydroxyethyl(2-methoxyethyl)amino]pyrimido[5,4-d]pyrimidin-6-yl]-(2-methoxyethyl)amino]ethanol(2,2'-(4,8-bis(diethylamino)pyrimido(5,4-d)pyrimidine-2,6-diyl)di(2-methoxyethyl)imino)diethanol2,2'-((4,8-bis(diethylamino)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis((2-methoxyethyl)azanediyl))bis(ethan-1-ol)
Show more names
RXRA-642RA-642BS2,2'-[4,8-Bis(diethylamino)pyrimido[5,4-d]pyrimidine-2,6-diyl]bis[(2-methoxyethyl)imino]bisethanolEthanol, 2,2'-[[4,8-bis(diethylamino)pyrimido[5,4-d]pyrimidine-2,6-diyl]bis[(2-methoxyethyl)imino]]bis-
RA 642BSRXRA 642orb1701733SCHEMBL9668239SCHEMBL30066743AKOS040747340Ethanol, 2,2'-((4,8-bis(diethylamino)pyrimido(5,4-d)pyrimidine-2,6-diyl)bis((2-methoxyethyl)imino))bis-CS-0077547
Properties
Computed structural properties
- XLogP
- 1.5
- Topological polar surface area
- 123 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 12
- Rotatable bonds
- 18
- Heavy atoms
- 36
- Formal charge
- 0
- Complexity
- 524
Chemistry & industry
Applications
DescriptionRA 642 is a PDE-inhibitor.
UsesRA642 is a compound with vasodilatory and hypertensive effects, with the activity of increasing arterial blood pressure, enhancing cerebral blood flow, reducing cerebrovascular resistance and peripheral resistance, and having a papaverine-like relaxant effect on smooth muscle in anesthetized animals.
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Compound notes
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