Basic information
- CAS
99295-33-7- Standard SMILES
CN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1- InChIKey
XFTVOHWWEQGXLS-UHFFFAOYSA-N- Molecular formula
- C17H18BrNO
- Average molar mass
- 332.2 g/mol
- Monoisotopic mass
- 331.05718
Overview
8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is a benzazepine.
Names & identifiers
- Preferred name
- 1H-3-benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-
- IUPAC
- 8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol
- English name
- 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide
- Molecular formula
- C17H18BrNO
- Molecular weight
- 332.23
Names & synonyms
1H-3-Benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-7-Bromo-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepineRefChem:9083268-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide99295-33-7SKF-835668-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-olSK&F-83566Skf 835668-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-olD203LR7XUSSK-83566
Show more names
159021SKF 83566 hydrobromiSKF 83566 HYDROBROMIDESKF-83566, 10 mM in DMSOnicotine craving|||dorsal striatum|||Inhibitor(+/-)-SKF-83566 HYDROCHLORIDE SELECTIVE DOPAMINE D17-bromo-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol hydrobromide
CHEMBL3240177-bromo-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol1H-3-Benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, (+/-)-SKF-83556UNII-D203LR7XUS8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-olBiomol-NT_000061
Properties
Computed structural properties
- XLogP
- 4
- Topological polar surface area
- 23.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 318
Physicochemical properties
- storage temp.
- Desiccate at RT
- solubility
- 45 % · 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: ≥14 mg/mL
- form
- solid
- color
- light tan
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 203 LR7XUS · D203LR7XUS
- WGK Germany
- 3 · 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Compounds that bind to and inhibit the action of ADENYLYL CYCLASES.
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Applications
UsesSKF 83566 Hydrobromide is a very potent and selective D1-like dopamine receptor antagonist, specifically at the 5-HT2 receptor.
Suppliers23 total
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
云南苏理生物医药科技有限公司0871-68355600 18787766125 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
无锡捷化医药科技有限公司83588313 18800520310 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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