Hexafluoroacetone

Excerpt from ERG Guide 125 [Gases - Toxic and/or Corrosive]:

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . ON FROSTBITE: rinse with plenty of water, do NOT remove clothes.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch or walk through spilled material.

Excerpt from NIOSH Pocket Guide for Hexafluoroacetone:

General First Aid:

(General first aid procedures)

· Wear positive pressure self-contained breathing apparatus (SCBA).

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 125 [Gases - Toxic and/or Corrosive]:

Immediate precautionary measure

Small spill:

Small spill:

TERRESTRIAL FATE: An estimated Koc of 150(1,SRC), based on an experimental log Kow(2), indicates that 1,1,1,3,3,3-hexafluoro-2-propanone will have moderate mobility in soil(3,SRC). In moist soils, 1,1,1,3,3,3-hexafluoro-2-propanone is expected to vigorously react with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate as well as liquid hydrates(4,5). If released to dry soils, 1,1,1,3,3,3-hexafluoro-2-propanone may quickly volatilize based on a vapor pressure of 5 mm Hg at 25 °C(6,SRC). 1,1,1,3,3,3-Hexafluoro-2-propanone on soil surfaces may photolyse(SRC); this compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide(7).

AQUATIC FATE: 1,1,1,3,3,3-Hexafluoro-2-propanone is expected to vigorously react with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate as well as liquid hydrates(1,2). This is expected to be a major fate process for 1,1,1,3,3,3-hexafluoro-2-propanone in aquatic systems(SRC). An estimated BCF value of 8(4), based on an experimental log Kow(3), indicates that 1,1,1,3,3,3-hexafluoro-2-propanone should not bioconcentrate in aquatic organisms(SRC).

ATMOSPHERIC FATE: Based on a vapor pressure of 5.0 mm Hg at 25 °C(1,SRC), as extrapolated from experimentally derived coefficients, 1,1,1,3,3,3-hexafluoro-2-propanone will exist solely in the vapor phase(2,SRC). 1,1,1,3,3,3-hexafluoro-2-propanone absorbs in the 220 to 400 nm region with a lambda max of 302 nm(2) and may thus directly photolyse(3,SRC). This compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide(3). The rate constant for the vapor-phase reaction of 1,1,1,3,3,3-hexafluoro-2-propanone with photochemically produced hydroxyl radicals has been estimated to be less than 1X10-16 cu cm/molecule-sec at 25 °C(4,SRC) indicating that 1,1,1,3,3,3-hexafluoro-2-propanone is essentially non-reactive and that degradation via hydroxyl radical reaction is not a major fate process for this compound in the atmosphere(SRC).

The substance can be absorbed into the body by inhalation and through the skin.

inhalation, skin absorption, skin and/or eye contact

Cough. Sore throat. Burning sensation. Laboured breathing. Shortness of breath. Symptoms may be delayed.

MAY BE ABSORBED! Redness. Pain. ON CONTACT WITH LIQUID: FROSTBITE.

Redness. Pain.

irritation eyes, skin, mucous membrane, respiratory system; pulmonary edema; liquid: frostbite; In Animals: teratogenic, reproductive effects; kidney injury

Based on an experimental log Kow of 1.46(1), the Koc of 1,1,1,3,3,3-hexafluoro-2-propanone is estimated as approximately 150 using a regression-derived equation(2,SRC). According to a suggested classification scheme(3), this estimated Koc value suggests that 1,1,1,3,3,3-hexafluoro-2-propanone has moderate mobility in soil(SRC).

1,1,1,3,3,3-Hexafluoro-2-propanone is widely used in the synthesis of polymers, medicinals, agriculture chemicals, and as a component of high-performance fluoropolymers and in the manufacture of the solvent 1,1,1,3,3,3-hexafluoro-2-propanol(1). It is also used as a chemical intermediate for hexafluoroisopropanol, polyacrylates used for textile coating, and polyester coatings for textiles; a solvent for acetal resins and polyamides; and a polymer adhesive(2). During 1,1,1,3,3,3-hexafluoro-2-propanone's production and subsequent use in the above products, it may be released to the environment through various waste streams(SRC).

A BCF of 8 was calculated for 1,1,1,3,3,3-hexafluoro-2-propanone, using an experimental log Kow of 1.46(1) and a recommended regression-derived equation(2,SRC). This BCF value suggests that 1,1,1,3,3,3-hexafluoro-2-propanone will not bioconcentrate in aquatic organisms(2,SRC).

The Henry's Law constant for 1,1,1,3,3,3-hexafluoro-2-propanone is estimated as 3.07X10-3 atm-cu m/mole(1,SRC). This indicates that 1,1,1,3,3,3-hexafluoro-2-propanone will volatilize from water surfaces(2,SRC). This compound's rapid rate of hydrolysis(3) indicates that hydrolysis should preclude volatilization in aquatic environments(SRC).

INHALATION EXPOSURES OF RATS INDICATED A 4-HR LETHAL CONCN OF 300 PPM; 200 PPM HFA (GAS) FOR 4 HR PRODUCED INJURY TO THE LIVER, KIDNEY, TESTES & THYMUS; & 100 PPM DAMAGED THE TESTES ONLY. DAILY, 6-HR REPEATED EXPOSURES OF RATS AT 60 PPM RESULTED IN DECREASED SPERMATOGENESIS AFTER 10 EXPOSURES & DECREASED BONE-MARROW ERYTHROPOIESIS AFTER TERMINATION OF EXPOSURE. TESTICULAR REGENERATION WAS STILL INCOMPLETE AT 57 DAYS FOLLOWING A SINGLE, 4-HR EXPOSURE AT 60 PPM HFA.

NINETY DAYS EXPOSURE AT 0.1 PPM RESULTED IN NO GROSS BIOCHEMICAL, HEMATOLOGIC OR HISTOPATHOLOGIC CHANGES IN EITHER RATS OR DOGS, ALTHOUGH THE LUNG WEIGHTS OF THE DOGS EXCEEDED THAT OF THE CONTROLS. AT 1 PPM, REVERSIBLE RENAL DYSFUNCTION IN RATS & INCREASED LUNG WEIGHT IN DOGS OVER THAT OF CONTROLS WAS ALL THAT WAS NOTED OF SIGNIFICANCE, NO HISTOPATHOLOGIC CHANGES. AT 12 PPM, SERIOUS TISSUE DAMAGE OCCURRED; THE RATE OF WEIGHT GAIN, ADRENAL & TESTES WEIGHTS OF MALE RATS, WERE LESS THAN THOSE OF CONTROLS. TRENDS TOWARD INCREASED WEIGHTS OF HEART, STOMACH, LIVER & LUNG WERE OBSERVED. IN ADDITION, THERE WAS EVIDENCE OF A TREND TOWARD LYMPHOCYTOSIS & RENAL DYSFUNCTION. HISTOPATHOLOGICALLY, SEVERE, BUT REVERSIBLE, TESTICULAR DAMAGE, & SLIGHT HYPERPLASIA OF THE SPLEEN, THYMUS, LYMPH NODES & BONE MARROW OCCURRED.

... SEVERE INJURY FROM 12 PPM LEVEL /HAS/ RESULTED IN DOGS; THE TESTES WEIGHT DECREASED, & THE WEIGHTS OF PITUITARY & LUNG INCREASED. DOGS ALSO DEVELOPED NEUTROPHILIA, HYPERGLYCEMIA, HYPOALBUMINERIA, & ANEMIA. AS WITH RATS, THE DOGS DEVELOPED SEVERE, BUT REVERSIBLE, TESTICULAR DAMAGE & SLIGHT HYPOPLASIA OF THE SPLEEN, THYMUS & LYMPH NODES. /FROM 90 DAYS INHALATION/

Testicular degeneration and atrophy were seen in rats given dermal doses of 65, 130, or 260 mg/kg 5 days/wk for 2 wk. These changes were still apparent 14 days after the last dose. They were not produced by a dermal dosage of 13 mg/kg for 14 days. The dose of 13 mg/kg/day HFA was considered a no-observed-effect level (NOEL). The structural changes (testicular atrophy) and altered lipid metabolism correlated well. In these studies, changes in steroidogenesis was due to inhibition in Leydig cells and was not due to a direct or immediate effect of HFA nor by hormonal mediation. HFA (as the sesquihydrate) was applied to the skin of pregnant rats at various dosages on days 6 through 16 of gestation. Maternal toxicity was observed at 90 mg/kg/day. The number of resorptions and live fetuses per litter suggested fetal toxicity at 25 mg/kg with fetal size being reduced at the 5 and 25 mg/kg doses (but not at 1 mg/kg). A small increase in soft tissue and external abnormalities was seen, but a definite teratogenic response could not be concluded. /Sesquihydrate/

For more Non-Human Toxicity Excerpts (Complete) data for 1,1,1,3,3,3-HEXAFLUORO-2-PROPANONE (11 total), please visit the HSDB record page.

1,1,1,3,3,3-Hexafluoro-2-propanone reacts readily with nucleophilic reagents(1). 1,1,1,3,3,3-Hexafluoro-2-propanone reacts vigorously with water(2). In water, this compound forms 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate. Further addition of water produces liquid hydrates. With ammonia and primary or secondary amines it forms stable 2,2-amino alcohols(1). 1,1,1,3,3,3-Hexafluoro-2-propanone absorbs in the 220 to 400 nm region with a lambda max of 302 nm(3). This compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide(3). Small amounts of CF3CO radical have also been detected in low temperature flash photolysis(3). The rate constant for the vapor phase reaction of 1,1,1,3,3,3-hexafluoro-2-propanone with photochemically produced hydroxyl radicals has been estimated to be less than 1X10-16 cu cm/molecule-sec at 25 °C(4,SRC); this indicates that 1,1,1,3,3,3-hexafluoro-2-propanone is essentially non-reactive and that degradation via hydroxyl radical reaction is not a major fate process for this compound in the atmosphere(SRC).

Hexafluoroacetone

15.67

45

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