Basic information
- CAS
146670-40-8- Standard SMILES
CC1(C)CCC(C)(C)c2cc(C3(c4ccc(C(=O)O)cc4)OCCO3)ccc21- InChIKey
ZZUKALQMHNSWTK-UHFFFAOYSA-N- Molecular formula
- C24H28O4
- Average molar mass
- 380.5 g/mol
- Monoisotopic mass
- 380.19875937
Overview
structure given in first source
Names & identifiers
- Preferred name
- SR 11237
- IUPAC
- 4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acid
- English name
- SR 11237
- Molecular formula
- C24H28O4
- Molecular weight
- 380.48
Names & synonyms
146670-40-8SR 11237SR11237SR-112374-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acidDTXSID101634334-(2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acidRefChem:932134DTXCID3085924BMS 649UVI 2108BMS649
Show more names
SR11237, 10 mM in DMSO4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoicacidBenzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-Retinoid X receptors,bone,BMS 649,transactivate,BMS649,Retinoic acid receptors,reporter,ossification,RAR/RXR,inhibit,Inhibitor,RXR/RXR,BMS-649,SR11237,homodimers,gene,SR-11237
BMS-6494-(2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acidBMS 1886494-(2-(5,6,7,8-Tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl)benzoic acidCHEMBL112715SCHEMBL2807932HMS3677L18AKOS024457615
Database identifiers
Properties
Computed structural properties
- XLogP
- 5.5
- Topological polar surface area
- 55.8 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 28
- Formal charge
- 0
- Complexity
- 581
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 28 mg/mL · DMSO: >28mg/mL (warmed)
- form
- powder
- color
- white to off-white
- InChI
- 1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)
- InChIKey
- ZZUKALQMHNSWTK-UHFFFAOYSA-N
- SMILES
- CC1(C)CCC(C)(C)c2cc(ccc12)C3(OCCO3)c4ccc(cc4)C(O)=O
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- WGK Germany
- 3 · 3
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Applications
UsesSR 11237 is a pan RXR agonist with without RAR activity. It is used in treatment of neurodegenerative diseases.
Suppliers39 total
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]
Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
Syntechem Co.,Ltd[email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
上海尺水药物研究有限公司[email protected] 13564957716 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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