E 0747
Basic information
- CAS
99599-78-7- Standard SMILES
CC1(C)CC2(NC(=O)N(CCCN3CCC(O)CC3)C2=O)c2cc(Cl)ccc2O1- InChIKey
VDDQRGRMFUGJDD-UHFFFAOYSA-N- Molecular formula
- C21H28ClN3O4
- Average molar mass
- 421.9 g/mol
- Monoisotopic mass
- 421.1768341
Overview
structure given in first source
Names & identifiers
- Preferred name
- E 0747
- IUPAC
- 6-chloro-3'-[3-(4-hydroxypiperidin-1-yl)propyl]-2,2-dimethylspiro[3H-chromene-4,5'-imidazolidine]-2',4'-dione
- English name
- E 0747
- Molecular formula
- C21H28ClN3O4
- Molecular weight
- 421.91772
Names & synonyms
99599-78-7E 0747E-0747Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2',5'-dione, 6-chloro-2,3-dihydro-1'-(3-(4-hydroxy-1-piperidinyl)propyl)-2,2-dimethyl-RefChem:136119Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2',5'-dione, 2,3-dihydro-6-chloro-2,2-dimethyl-1'-(3-(4-hydroxy-1-piperidinyl)propyl)-6-chloro-3'-[3-(4-hydroxypiperidin-1-yl)propyl]-2,2-dimethylspiro[3H-chromene-4,5'-imidazolidine]-2',4'-dioneorb1703482SCHEMBL10464144DTXSID00912614AKOS040745762HY-106749
Show more names
L-290656-chloro-2,2-dimethyl-1'-[3-(4-hydroxypiperidino)propyl]spiro[chroman-4,4'-imidazolidine]-2',5'-dione6-Chloro-2,3-dihydro-1'-[3-(4-hydroxy-1-piperidinyl)propyl]-2,2-dimethylspiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione
T240216-Chloro-2'-hydroxy-1'-[3-(4-hydroxypiperidin-1-yl)propyl]-2,2-dimethyl-2,3-dihydrospiro[[1]benzopyran-4,4'-imidazol]-5'(1'H)-one6-Chloro-2'-hydroxy-1'-[3-(4-hydroxypiperidin-1-yl)propyl]-2,2-dimethyl-2,3-dihydrospiro[1-benzopyran-4,4'-imidazol]-5'(1'H)-one
Database identifiers
- CAS
99599-78-7- PubChem CID
- 127372
- DTXSID
DTXSID00912614- Nikkaji
- J228.008F、J487.965A、J487.966J
Properties
Computed structural properties
- XLogP
- 2.3
- Topological polar surface area
- 82.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 4
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 652
Chemistry & industry
Applications
DescriptionE 0747 is an antiarrhythmic agent of class 1C type of the Vaughan Williams' classification. E-0747 suppresses arrhythmia by inhibiting Na channels of cardiac cells and is expected to become a clinically useful antiarrhythmic drug.
UsesE-0747 is an antiarrhythmic drug that inhibits arrhythmias by inhibiting Na[+] channels in cardiomyocytes[1].
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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