Basic information
- CAS
76931-93-6- Standard SMILES
CC(=O)SCC(=O)ON1C(=O)CCC1=O- InChIKey
FLCQLSRLQIPNLM-UHFFFAOYSA-N- Molecular formula
- C8H9NO5S
- Average molar mass
- 231.23 g/mol
- Monoisotopic mass
- 231.02014356
Names & identifiers
- Preferred name
- N-Hydroxysuccinimide S-acetylthioacetate
- IUPAC
- (2,5-dioxopyrrolidin-1-yl) 2-acetylsulfanylacetate
- English name
- N-Succinimidyl S-Acetylthioglycolate
- Molecular formula
- C8H9NO5S
- Molecular weight
- 231.23
Names & synonyms
76931-93-6SATAN-Succinimidyl-S-acetylthioacetateHSATAN-Hydroxysuccinimide S-acetylthioacetateDTXSID40227719S-Acetylthioacetic acid N-hydroxysuccinimide esterEthanethioic acid, S-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl] esterEthanethioic acid, S-(2-((2,5-dioxo-1-pyrrolidinyl)oxy)-2-oxoethyl) esterRefChem:163566DTXCID401502102,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate
Show more names
SKL356SATA[573100]SUCCINIMIDYL ACETYLTHIOACETATEN-SUCCINIMIDYL (ACETYLTHIO)ACETATES-ACETYLTHIOGLYCOLIC ACID NHS ESTER
N-Succinimidyl S-acetylthioglycolate(2,5-dioxopyrrolidin-1-yl) 2-acetylsulfanylacetateN-Succinimidyl S-acetylthioacetateMFCD00036891(SATA);N-SUCCINIMIDYL S-ACETYLTHIOACETATES-acetyl 2-(2,5-dioxopyrrolidin-1-yl)ethanethioateSATA Protein ModifierN-Succinimidyl S-acetylthioacetate (SATA)
Database identifiers
- CAS
76931-93-6
Properties
Computed structural properties
- XLogP
- -0.3
- Topological polar surface area
- 106 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 5
- Heavy atoms
- 15
- Formal charge
- 0
- Complexity
- 311
Physicochemical properties
- Melting point
- 84 · 84-89 °C
- Boiling point
- 337.3 · 337.3±44.0 °C(Predicted)
- Density
- 1.46 · 1.46±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- solubility
- 50 mg/mL · acetonitrile: 50 mg/mL
- form
- powder
- color
- White to Off-White
- BRN
- 7815491 · 7815491
- Stability
- Moisture Sensitive
- InChI
- InChI=1S/C8H9NO5S/c1-5(10)15-4-8(13)14-9-6(11)2-3-7(9)12/h2-4H2,1H3
- InChIKey
- FLCQLSRLQIPNLM-UHFFFAOYSA-N
- SMILES
- C(ON1C(=O)CCC1=O)(=O)CSC(C)=O
- UNSPSC Code
- 41116133 · 41116133
- NACRES
- 47 · NA.47
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
Safety & regulation
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (100%)；Eye Irrit. 2 (100%)；STOT SE 3 (50%)
Safety data
- F
- 3-10-23
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- hs_code
- 29309090
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 25/26
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Chemistry & industry
Applications
UsesThiolating reagent for primary amines; thiol can be deprotected under mild conditions. Typically, couples initially to a molecule containing primary amine by amide bond buffered at pH 7.5. Deprotection may be accomplished with 0.05 M hydroxylamine at neutral pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
UsesN-Succinimidyl S-Acetylthioglycolate can be used as Thiolating reagent for primary amines; thiol can be deprotected under mild conditions and be useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
UsesReacts with primary amines to add protected sulfhydryls.
Suppliers100 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
江苏吉泰肽业科技有限公司051580855088 18762539991 · [email protected]
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
温州共赢化学有限公司+86-0086-577-64498589 +86-15355981851 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
上海超悦化学科技有限公司（原上海斯比德化学）21-65679720 · [email protected]
上海迈瑞尔生化科技有限公司
Related reactions
1 records
Compound notes
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