Basic information
- CAS
101141-95-1- Standard SMILES
N[C@@H](Cc1ccc(OP(=O)(O)O)c(O)c1)C(=O)O- InChIKey
YNDMEEULGSTYJT-LURJTMIESA-N- Molecular formula
- C9H12NO7P
- Average molar mass
- 277.17 g/mol
- Monoisotopic mass
- 277.03513835
Overview
Foslevodopa is an L-tyrosine derivative that is L-dopa in which the hydroxy group at position 4' is replaced by a phosphonooxy group. It is a water-soluble prodrug of levodopa which is used for the treatment of Parkinson's disease. It has a role as an antiparkinson drug and a prodrug. It is an O-phosphoamino acid, a L-tyrosine derivative and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-dopa.
Names & identifiers
- Preferred name
- Foslevodopa
- IUPAC
- (2S)-2-amino-3-(3-hydroxy-4-phosphonooxyphenyl)propanoic acid
- English name
- DOPA 4-phosphate
- Molecular formula
- C9H12NO7P
- Molecular weight
- 277.167841
Names & synonyms
Foslevodopa97321-87-4Levodopa-4'-monophosphate3-hydroxy-O-phosphono-L-tyrosineFoslevodopa [USAN](2S)-2-amino-3-(3-hydroxy-4-phosphonooxyphenyl)propanoic acid37NQZ0J76IFOSLEVODOPA [INN]FOSLEVODOPA [JAN]ABBV-951 COMPONENT FOSLEVODOPAL-TYROSINE, 3-HYDROXY-O-PHOSPHONO-L-TYROSINE, 3-HYDROXY-, 4-(DIHYDROGEN PHOSPHATE)
Show more names
DOPA 4-PHOSPHONATE
foslevodopumRefChem:600352Dopa 4-phosphateABBV-951101141-95-1UNII-37NQZ0J76IWHO 11006(S)-2-amino-3-(3-hydroxy-4-(phosphonooxy)phenyl)propanoic acid
Database identifiers
- CAS
101141-95-1、97321-87-4- PubChem CID
- 127766
- DTXSID
DTXSID70905957- ChEMBL
CHEMBL4594379- ChEBI
CHEBI:192509- UNII
- 37NQZ0J76I
- Nikkaji
- J3.795.603A
Properties
Computed structural properties
- XLogP
- -4
- Topological polar surface area
- 150 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 5
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 344
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Chemistry & industry
Suppliers12 total
上海沛灵生物科技有限公司13127581762 13127581762 · [email protected]
Hefei TianRui Pharmaceutical Chemical Co., Ltd.+86-0551-68665055 +86-+86-18616906106 · [email protected]
合肥天瑞药物化学有限公司0551-68933033 13956024211
Chongqing jooe co., ltd+86-15223382610 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
成都同创源医药科技有限公司028-83379370 13880556291 · [email protected]
上海康满林生物医药有限公司68080707 15021879576 · [email protected]
济南尚博医药股份有限公司0531-61320525 15866703830 · [email protected]
上海智乾生物科技有限公司[email protected]
济南尚博生物科技有限公司+8615866703830 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
南京沃格尼化工有限公司15996452985 · [email protected]
Additional notes
DefinitionChEBI: Foslevodopa is an L-tyrosine derivative that is L-dopa in which the hydroxy group at position 4' is replaced by a phosphonooxy group. It is a water-soluble prodrug of levodopa which is used for the treatment of Parkinson's disease. It has a role as an antiparkinson drug and a prodrug. It is a L-tyrosine derivative, a non-proteinogenic L-alpha-amino acid and an O-phosphoamino acid. It is functionally related to a L-dopa.
Related reactions
1 records
Compound notes
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