Basic information
- CAS
102671-35-2- Standard SMILES
O=C(Nc1ccncc1)NN1CC=CCC1- InChIKey
QKXWNCGIAHHUNW-UHFFFAOYSA-N- Molecular formula
- C11H14N4O
- Average molar mass
- 218.26 g/mol
- Monoisotopic mass
- 218.11676108
Names & identifiers
- Preferred name
- FR 64822
- IUPAC
- 1-(3,6-dihydro-2H-pyridin-1-yl)-3-pyridin-4-ylurea
- English name
- FR 64822
- Molecular formula
- C11H14N4O
- Molecular weight
- 218.26
Names & synonyms
FR 64822102671-35-2FR-64822DTXSID80145448FR64822Urea, N-(3,6-dihydro-1(2H)-pyridinyl)-N'-4-pyridinyl-RefChem:141439DTXCID4067939N-(4-Pyridylcarbamoyl)amino 1,2,3,6-tetrahydropyridine1-(3,6-dihydro-2H-pyridin-1-yl)-3-pyridin-4-ylureaQKXWNCGIAHHUNW-UHFFFAOYSA-Norb1700566
Show more names
N-[[(1,2,5,6-Tetrahydropyridin)-1-ylamino]carbonyl]-4-pyridinamine
SCHEMBL7372047AKOS040748385HY-105294T27363N-(3,6-Dihydropyridin-1(2H)-yl)-N'-(pyridin-4-yl)ureaN-[(4-pyridylcarbamoyl)amino]-1,2,3,6-tetrahydropyridine
Database identifiers
- CAS
102671-35-2- PubChem CID
- 128144
- DTXSID
DTXSID80145448- Nikkaji
- J435.407I
Properties
Computed structural properties
- XLogP
- 0.8
- Topological polar surface area
- 57.3 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 16
- Formal charge
- 0
- Complexity
- 261
Physicochemical properties
- Density
- 1.24 · 1.24±0.1 g/cm3(Predicted)
- pka
- 10.93 · 10.93±0.20(Predicted)
Chemistry & industry
Applications
DescriptionFR 64822 is a novel non-opioid antinociceptive compound. It displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptive activity in the acetic acid writhing test (ED50 = 1.8 mg/kg p.o.).
UsesFR 64822 is a dopamine D2 receptor agonist that can induce antinociceptive activity in rats and mice by indirectly stimulating dopamine D2 receptors. FR 64822 can promote penile erection in juvenile rats and improve amnesia in rats induced by scopolamine during passive avoidance tasks[1].
Suppliers6 total
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海德轩医药科技有限公司[email protected] · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
1 records
Compound notes
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