Basic information
- CAS
103176-67-6- Standard SMILES
O=C(Nc1cccc2c1OC(c1nn[nH]n1)CO2)c1ccc(OCCCCc2ccccc2)cc1- InChIKey
CILFBYXDVWMEGJ-UHFFFAOYSA-N- Molecular formula
- C26H25N5O4
- Average molar mass
- 471.5 g/mol
- Monoisotopic mass
- 471.1906543
Overview
SRS-A antagonist
Names & identifiers
- Preferred name
- Ono-RS 347
- IUPAC
- 4-(4-phenylbutoxy)-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide
- English name
- Ono-RS-347
- Molecular formula
- C26H25N5O4
- Molecular weight
- 471.51
Names & synonyms
Ono-RS 347Ono-RS-347135556-20-6RefChem:168300103176-67-64-(4-phenylbutoxy)-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideCHEMBL1728898-(4-(4-Phenylbutoxy)benzoyl)amino-2-(tetrazol-5'-yl)benzo-1,4-dioxaneorb1699758SCHEMBL8162396DTXSID10908220BDBM50227047
Show more names
Benzamide, N-[2,3-dihydro-3-(2H-tetrazol-5-yl)-1,4-benzodioxin-5-yl]-4-(4-phenylbutoxy)-
AKOS040749083N-(3-(1H-tetrazol-5-yl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-4-(4-phenylbutoxy)benzamideHY-113693T28253Benzamide, N-(2,3-dihydro-3-(1H-tetrazol-5-yl)-1,4-benzodioxin-5-yl)-4-(4-phenylbutoxy)-
Database identifiers
- CAS
103176-67-6- PubChem CID
- 128237
- DTXSID
DTXSID10908220- ChEMBL
CHEMBL172889- Nikkaji
- J444.184B
Properties
Computed structural properties
- XLogP
- 4.2
- Topological polar surface area
- 111 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 9
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 656
Physicochemical properties
- Melting point
- 153 · 153-155 °C
- Density
- 1.333 · 1.333±0.06 g/cm3(Predicted)
- pka
- 3.93 · 3.93±0.10(Predicted)
Chemistry & industry
Applications
DescriptionOno-RS 347 is an SRS-A antagonist. It is a new leukotriene antagonists.
UsesONO-RS-347 is an orally active and potent antagonist of leukotriene C4 and D4. ONO-RS-347 inhibits LTD4-induced bronchoconstriction in guinea pigs. ONO-RS-347 is promising for research of allergic asthma and other immediate hypersensitivty diseases[1].
Suppliers4 total
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
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Compound notes
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