HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(5-Methyl-2-thiazolyl)amino]-2-oxoacetic acid
Meloxicam Impurity 15 · 2-((5-methylthiazol-2-yl)amino)-2-oxoacetic acid · 2-[(5-Methyl-2-thiazolyl)amino]-2-oxoacetic Acid · Acetic acid, 2-[(5-methyl-2-thiazolyl)amino]-2-oxo-
![2-[(5-Methyl-2-thiazolyl)amino]-2-oxoacetic acid molecular structure](/img/chemical/12831783.png)
Identifiers & Physical Properties
| CAS No. | 82514-69-0 |
|---|---|
| Molecular formula | C6H6N2O3S |
| Average molar mass | 186.19 g/mol |
| Monoisotopic mass | 186.00991323 g/mol |
| SMILES | Cc1cnc(NC(=O)C(=O)O)s1 |
| InChIKey | YSLGGTIITFTBBY-UHFFFAOYSA-N |
| PubChem CID | 12831783 |
| DTXSID | DTXSID901238704 |
Chemical & Physical Properties
| XLogP | 0.8 |
|---|---|
| Topological polar surface area | 108 |
| Hydrogen bond donors | 2 |
| Hydrogen bond acceptors | 5 |
| Rotatable bonds | 2 |
| Heavy atoms | 12 |
| Formal charge | 0 |
| Complexity | 209 |
| Density | 1.603±0.06 g/cm3(Predicted) |
| pKa (acidity coefficient) | -0.88±0.20(Predicted) |
Applications & Uses
Uses
2-[(5-Methyl-2-thiazolyl)amino]-2-oxoacetic Acid is a metabolite of Meloxicam (M216100(P)), that was studied in human liver microsomes. Meloxicam is a preferential cyclooxygenase (COX-2) inhibitor. Sudoxicam and Meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.