Carbobenzoxyglycyl-prolyl-arginine-4-nitroanilide
Basic information
- CAS
66648-35-9- Standard SMILES
NC(N)=NCCC[C@H](Nc1ccc([N+](=O)[O-])cc1)C(=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)OCc1ccccc1- InChIKey
MVFKEZJRNZUQPK-VXKWHMMOSA-N- Molecular formula
- C27H34N8O7
- Average molar mass
- 582.6 g/mol
- Monoisotopic mass
- 582.25504545
Overview
chromogenic aminopeptidase substrate
Names & identifiers
- Preferred name
- Carbobenzoxyglycyl-prolyl-arginine-4-nitroanilide
- IUPAC
- benzyl N-[2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-(4-nitroanilino)pentanoyl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]carbamate
- English name
- Z-GLY-PRO-ARG-PNA
- Molecular formula
- C27H34N8O7
- Molecular weight
- 582.61
Names & synonyms
Cbz-gly-pro-arg-p-NADTXSID30985230Carbobenzoxyglycyl-prolyl-arginine-4-nitroanilideRefChem:123531DTXCID10141242766648-35-9benzyl N-[2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-(4-nitroanilino)pentanoyl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]carbamateL-Argininamide, N-((phenylmethoxy)carbonyl)glycyl-L-prolyl-N-(4-nitrophenyl)-N-[(Benzyloxy)carbonyl]glycyl-N-[(2S)-5-(carbamimidoylamino)-2-(4-nitroanilino)pentanoyl]-L-prolinamideZ-GPR-pNAZ-GLY-PRO-ARG-PNACbz-Gly-Pro-Arg-pNA
Show more names
Z-Gly-Pro-Arg-pNA acetateL-Argininamide, N-[(phenylmethoxy)carbonyl]glycyl-L-prolyl-N-(4-nitrophenyl)- (9CI)
Database identifiers
- CAS
66648-35-9
Properties
Computed structural properties
- XLogP
- 1.4
- Topological polar surface area
- 227 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 13
- Heavy atoms
- 42
- Formal charge
- 0
- Complexity
- 970
Physicochemical properties
- Density
- 1.439 · 1.439±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- storage temp.
- -20 °C · -20°C
- solubility
- 20 mg/mL, · methanol: 20mg/mL, clear, colorless to light yellow
- form
- powder
- pka
- 11.344 · 11.344±0.46(predicted)
- Sequence
- {Z-Gly}-Pro-Arg-{pNA}
- InChIKey
- FPMAXHHYPVIJMC-VROPFNGYSA-N
- SMILES
- CC(O)=O.NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)OCc2ccccc2)C(=O)Nc3ccc(cc3)[N+]([O-])=O
- UNSPSC Code
- 12352204 · 12352204
- NACRES
- 32 · NA.32
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- WGK Germany
- 3 · 3
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Applications
UsesZ-Gly-Pro-Arg p-nitroanilide acetate salt has been used as a substrate in prostate-specific antigen (PSA) activation protease assay for determining enterokinase-PSA-trypsin (EK-PSA-TRP) activity and to perform kinetic experiments. It has also been used as a substrate to measure the pancreatic trypsin activity chromogenically.
Suppliers
Loading…
Open inquiries
Loading…
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…