Basic information
- CAS
120128-14-5- Standard SMILES
C[C@@H](O)C(=[N+]=[N-])C(=O)OC[C@H](N)C(=O)O- InChIKey
WAKGSHQRLIGGLB-DMTCNVIQSA-N- Molecular formula
- C7H11N3O5
- Average molar mass
- 217.18 g/mol
- Monoisotopic mass
- 217.06987046
Overview
Thrazarine has been reported in Streptomyces and Streptomyces coerulescens with data available.
Names & identifiers
- Preferred name
- O-((3R)-2-Diazo-3-hydroxybutyryl)-L-serine
- IUPAC
- (2S)-2-amino-3-[(3R)-2-diazo-3-hydroxybutanoyl]oxypropanoic acid
- English name
- thrazarine
- Molecular formula
- C7H11N3O5
- Molecular weight
- 217.18
Names & synonyms
O-((3R)-2-Diazo-3-hydroxybutyryl)-L-serine(2S)-2-amino-3-[(3R)-2-diazo-3-hydroxybutanoyl]oxypropanoic acidO-((R)-2-diazo-3-hydroxybutanoyl)-L-serineL-Serine, 2-diazo-3-hydroxybutanoate (ester), (R)-orb1701521SCHEMBL10421512AKOS040747539HY-122341CS-0084024T26275FR-900840thrazarine
Show more names
Antibiotic FR-900840O-[(R)-2-Diazo-3-hydroxy-1-oxobutyl]-L-serine
Database identifiers
- CAS
120128-14-5- PubChem CID
- 129042
- Nikkaji
- J261.794C
Properties
Computed structural properties
- XLogP
- -3.5
- Topological polar surface area
- 112 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 6
- Heavy atoms
- 15
- Formal charge
- 0
- Complexity
- 310
Physicochemical properties
- Melting point
- 123 · 123-125 °C
Chemistry & industry
Applications
UsesThrazarine (FR 900840) is an oncology antibiotic that can be produced by Streptomyces coerulescens MH802-fF5. Thrazarine directly inhibits DNA synthesis and tumor cell growth. Thrazarine can specifically induce lysis of tumor cells co-cultured with non-activated macrophages. Thrazarine is used in cancer research[1].
Suppliers2 total
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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