Basic information
- CAS
105798-74-1- Standard SMILES
Nc1ncnc(N[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1[N+](=O)[O-]- InChIKey
OHEMBWZZEKCBAS-UUOKFMHZSA-N- Molecular formula
- C9H13N5O6
- Average molar mass
- 287.23 g/mol
- Monoisotopic mass
- 287.08658315
Overview
Clitocine is a N-glycosyl compound.
Names & identifiers
- Preferred name
- Clitocine
- IUPAC
- (2R,3R,4S,5R)-2-[(6-amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol
- English name
- clitocine
- Molecular formula
- C9H13N5O6
- Molecular weight
- 287.231
Names & synonyms
Clitocine105798-74-1(2R,3R,4S,5R)-2-[(6-amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol9Z4QXQ98QW6-Amino-5-nitro-4-(ribofuranosylamino)pyrimidineDTXSID30909739(2R,3R,4S,5R)-2-((6-amino-5-nitropyrimidin-4-yl)amino)-5-(hydroxymethyl)oxolane-3,4-diolRefChem:918827DTXCID0013387992-((6-amino-5-nitropyrimidin-4-yl)amino)-5-(hydroxymethyl)oxolane-3,4-diolCHEMBL304179N-(6-Amino-5-nitro-4-pyrimidinyl)-beta-D-ribofuranosylamine
Show more names
N-(6-Amino-5-nitro-4-pyrimidinyl)-β-D-ribofuranosylamineb-D-RibofuranosylaMine, N-(6-aMino-5-nitro-4-pyriMidinyl)-β-D-Ribofuranosylamine, N-(6-amino-5-nitro-4- pyrimidinyl)-N-?(6-?amino-?5-?nitro-?4-?pyrimidinyl)?-β-?D-?Ribofuranosylamine
beta-D-Ribofuranosylamine, N-(6-amino-5-nitro-4-pyrimidinyl)-starbld0000883UNII-9Z4QXQ98QWSCHEMBL182039orb1697760CHEBI:178144BDBM50100587AKOS040751216
Properties
Computed structural properties
- XLogP
- -0.4
- Topological polar surface area
- 180 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 3
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 354
Physicochemical properties
- form
- Solid
- color
- White to off-white
- FDA UNII
- 9 Z4QXQ98QW · 9Z4QXQ98QW
Chemistry & industry
Applications
UsesClitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity[1][2].
Suppliers22 total
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
Aladdin Scientific[email protected]
宁波亿诺化学品有限公司86-574-27787657 · [email protected]
Hangzhou Sage Chemical Co., Ltd.+86057186818502 13588463833 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
杭州六可生物科技有限公司+86-571-86912261 19975279805 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
上海源叶生物科技有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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