2,3-Dichloro-5-((4S)-6,8-dichloro-4H-1,3-benzodioxin-4-yl)-4-nitro-1H-pyrrole

DescriptionDioxapyrrolomycin, a tricyclic pyrrole-containing antibiotic isolated first from Streptomyces fumanus Sveshnikova in the mid-1980s, displays moderate insecticidal and acaricidal activity, but systematic structural changes led to novel synthetic pyrrole derivatives with increased insecticidal activity and mammalian safety (40). The natural product and its synthetic congeners are uncouplers of mitochondrial oxidative phosphorylation.

UsesPyrroxamycin is a novel antibiotic produced by Streptomyces, whose chemical structure was determined by chemical properties and X-ray crystallography and 13C NMR spectroscopy analysis. It is active against Gram-positive bacteria and dermatophytes. In this paper, the authors discuss the taxonomy, fermentation, isolation, physicochemical properties, chemical structure, and biological activity of the strain producing Pyrroxamycin.