Basic information
- CAS
106134-33-2- Standard SMILES
Cc1cccc(C)c1N(CCCc1cccnc1)C(=O)C(C)N.Cl.Cl- InChIKey
VLIYADXYDUEILX-UHFFFAOYSA-N- Molecular formula
- C19H27Cl2N3O
- Average molar mass
- 384.3 g/mol
- Monoisotopic mass
- 383.1531179
Overview
structure given in first source; RN given for (+-)-isomer; RN for compound without isomeric designation not available 10/92
Names & identifiers
- Preferred name
- Ro 22-9194
- IUPAC
- 2-amino-N-(2,6-dimethylphenyl)-N-(3-pyridin-3-ylpropyl)propanamide;dihydrochloride
- English name
- Ro 22-9194
- Molecular formula
- C19H27Cl2N3O
- Molecular weight
- 384.34318
Names & synonyms
Ro 22-9194106134-33-2DTXSID4048775Ro-22-9194DTXCID4028701RefChem:1796412-Amino-N-(2,6-dimethylphenyl)-N-(3-(3-pyridyl)propyl)propionamide2-amino-N-(2,6-dimethylphenyl)-N-(3-pyridin-3-ylpropyl)propanamide;dihydrochlorideVLIYADXYDUEILX-UHFFFAOYSA-NNCGC00183832-01orb1699498SCHEMBL7904048
Show more names
Ro 229194,Ro 22 9194
CHEMBL2359725Tox21_113250AKOS040749323DA-57475HY-114846CAS-106134-33-2CS-0064460T28567
Database identifiers
- CAS
106134-33-2- PubChem CID
- 129209
- DTXSID
DTXSID4048775- ChEMBL
CHEMBL2359725
Properties
Computed structural properties
- Topological polar surface area
- 59.2 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 6
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 364
Chemistry & industry
Applications
DescriptionRo 22-9194 is a new class I antiarrhythmic agent. Ro 22-9194 (10 μM) caused a concentration-dependent decrease in the maximum upstroke velocity (Vmax) and shortening of action potential duration in guinea-pig ventricular cells.
UsesRo 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action[1][2].
Suppliers3 total
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
2 records
Compound notes
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