Glycidaldehyde

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic; polymerization hazard]:

General First Aid:

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U126, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds. A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A good candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for GLYCIDALDEHYDE (7 total), please visit the HSDB record page.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synth & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/

For more Preventive Measures (Complete) data for GLYCIDALDEHYDE (10 total), please visit the HSDB record page.

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic; polymerization hazard]:

Immediate precautionary measure

0.17 [ppm]

1.8 [ppm]

11 [ppm]

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic; polymerization hazard]:

Preferred respirators incl gas masks with organic vapor cannisters and high-efficiency particulate filters or supplied-air respirators. All body surfaces should be protected against contact with epoxy cmpd through the use of gloves, aprons, face shields, goggles and other protective equipment and clothing as necessary. /Epoxy cmpd/

PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent /should be available./ ... Safety pipettes should be used for all pipetting. ... In animal laboratory, personnel should ... wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. ... gowns ... /should be/ of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/

TERRESTRIAL FATE: Glycidaldehyde is expected to hydrolyze rapidly in moist soil based data for a structurally similar compound, glycidol, which has a chemical hydrolysis half-life of 12 days(1). Based on a classification scheme(2), an estimated Koc value of 1(SRC), determined from a structure estimation method(3), indicates that glycidaldehyde is expected to have very high mobility in soil(SRC). Volatilization of glycidaldehyde from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.1X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Epoxides, such as glycidaldehyde, are expected to react with organic matter in soils and sediment(SRC). The potential for volatilization of glycidaldehyde from dry soil surfaces may exist(SRC) based upon an estimated vapor pressure of 45 mm Hg(SRC), determined from a fragment constant method(5). Glycidaldehyde is expected to biodegrade rapidly based on the biodegradation of a structurally similar compound, glycidol(SRC). Ring-opening of glycidol to glycerol occurs spontaneously in aqueous solutions but is accelerated through microbial activity(1). Under aerobic and anaerobic conditions, levels of glycidol (initial concn = 100 ppm) were below the detection limit of 0.6 ppm after about 10 days in inoculated nutrient broth cultures(1).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that glycidaldehyde is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 5.1X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Epoxides, such as glycidaldehyde, are expected to react with organic matter in water(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Glycidaldehyde is expected to biodegrade rapidly based on the biodegradation of a structurally similar compound, glycidol(SRC). Ring-opening of glycidol to glycerol occurs spontaneously in aqueous solutions but is accelerated through microbial activity(7). Under aerobic and anaerobic conditions, levels of glycidol (initial concn = 100 ppm) were below the detection limit of 0.6 ppm after about 10 days in inoculated nutrient broth cultures(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), glycidaldehyde, which has an estimated vapor pressure of 45 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase glycidaldehyde is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 22.8 hrs(SRC), calculated from its rate constant of 1.7X10-11 cu cm/molecule-sec at 25 °C(3).

Glycidylaldehyde occurs in sunflower oil, and its concentration increases with that of peroxides during storage, causing deterioration of the flavor. To maintain high quality of the oil, peroxides should not exceed 0.25% and glycidylaldehyde not more than 0.46%(1). Glycidylaldehyde has been detected in rancid samples of commercial lard(1).

Glycidaldehyde

Endocrine

4 x 10 ^-4 mg/kg-day

PRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/

Using a structure estimation method based on molecular connectivity indices(1), the Koc for glycidaldehyde can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that glycidaldehyde is expected to have very high mobility in soil(SRC).

Glycidaldehyde will produce marked skin irritation and sensitization, but effective hygiene practices should prevent exposure.

Glycidaldehyde is moderately toxic following dermal exposure, and is extremely irritating to the skin. It is a moderate eye and respiratory tract irritant. It is mutagenic in vitro in nonmammalian assays, and is a skin carcinogen in rodents.

Can cause stimulation of CNS followed by depression.

Human systemic effects by inhalation: changes in CNS electrical activity, olfactory changes, and excitement.

Glycidaldehyde's former production and use as a crosslinking agent for the finishing of wool; and for the tanning and fat liquoring of leather and surgical sutures(1) may result in its release to the environment through various waste streams(SRC).

Glycidaldehyde is expected to biodegrade rapidly based on the biodegradation of a structurally similar compound, glycidol(SRC). Ring-opening of glycidol to glycerol occurs spontaneously in aqueous solutions but is accelerated through microbial activity(1). Under aerobic and anaerobic conditions, levels of glycidol (initial concn = 100 ppm) were below the detection limit (i.e., 0.6 ppm) after about 10 days in inoculated nutrient broth cultures(1).

Glycidaldehyde

Group 2B: Possibly carcinogenic to humans

Volume 11: (1976) Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anaesthetics

1999

1998

An estimated BCF of 3 was calculated for glycidaldehyde(SRC), using an estimated log Kow of -0.12(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

U126; As stipulated in 40 CFR 261.33, when glycidaldehyde, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).