Basic information
- CAS
766-09-6- Standard SMILES
CCN1CCCCC1- InChIKey
HTLZVHNRZJPSMI-UHFFFAOYSA-N- Molecular formula
- C7H15N
- Average molar mass
- 113.2 g/mol
- Monoisotopic mass
- 113.12044948
Overview
1-ethylpiperidine appears as a colorless liquid with the odor of pepper. Less dense than water. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.
Names & identifiers
- Preferred name
- N-Ethylpiperidine
- IUPAC
- 1-ethylpiperidine
- English name
- 1-Ethylpiperidine
- Molecular formula
- C7H15N
- Molecular weight
- 113.2
Names & synonyms
1-Ethylpiperidine766-09-6N-ETHYLPIPERIDINEPiperidine, 1-ethyl-N-AethylpiperidinNSC-20907IE43L0926DTXSID1061102CHEBI:39017EPHP cpdRefChem:75778DTXCID5047900
Show more names
N-Ethylpiperidin1-Ethylpiperidin1-Ethylpiperidene1-ethvlpiperidine1-ethyl-piperidin
212-161-6N-Ethyl piperidineethylpiperidine1-ethyl-piperidineMFCD00006507NSC 2090N-Aethylpiperidin [German]1-ethyl piperidine
Database identifiers
- CAS
766-09-6- PubChem CID
- 13007
- DTXSID
DTXSID1061102- ChEMBL
CHEMBL25053- ChEBI
CHEBI:39017- UNII
- 7IE43L0926
- EC Number
- 212-161-6
- Nikkaji
- J35.452J
Properties
Computed structural properties
- XLogP
- 2
- Topological polar surface area
- 3.2 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 1
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 55.4
Experimental & physicochemical properties
Chemical ClassesFlammable agents - 3rd degree
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
LogP1.88
Physical Description
1-ethylpiperidine appears as a colorless liquid with the odor of pepper. Less dense than water. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.
Liquid
Physicochemical properties
- Melting point
- -20 °C · -20 °C
- Boiling point
- 131 °C · 131 °C(lit.)
- Density
- 0.824 g/mL · 0.824 g/mL at 25 °C(lit.)
- vapor pressure
- 12.76 hPa · 12.76hPa at 20℃
- refractive index
- 20 · n20/D 1.444(lit.)
- Flash point
- 66 °F · 66 °F
- storage temp.
- Flammables area
- solubility
- 1 · 1-ethylpiperidine salt of benzylpenicillin is considerably less soluble in amyl acetate and acetone.
- pka
- 10.45 · 10.45(at 23℃)
- form
- Liquid
- color
- Clear colorless to slightly yellow
- PH
- 12.2 · 12.2 (50g/l, H2O, 20℃)
- explosive limit
- 1.9 · 1.9-12.1%(V)
- Water Solubility
- 50 G/L · 50 G/L
- BRN
- 102643 · 102643
- Henry's Law Constant
- 3.9 · 3.9×10-1 mol/(m3Pa) at 25℃, Hilal et al. (2008)
- InChI
- 1S/C7H15N/c1-2-8-6-4-3-5-7-8/h2-7H2,1H3
- InChIKey
- HTLZVHNRZJPSMI-UHFFFAOYSA-N
- SMILES
- CCN1CCCCC1
- LogP
- 1.89 at · 1.89 at 25℃
- CAS DataBase Reference
- 766 · 766-09-6(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 7 IE43L0926 · 7IE43L0926
- NIST Chemistry Reference
- 1 · Piperidine, 1-ethyl-(766-09-6)
- EPA Substance Registry System
- 1 · Piperidine, 1-ethyl- (766-09-6)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 2 · GHS02,GHS05,GHS07
- Signal word
- Danger
- Hazard statements
- 302 · H302+H312+H332-H314-H225
- Precautionary statements
- 501 · P501-P261-P270-P240-P210-P233-P243-P241-P242-P271-P264-P280-P370+P378-P362+P364-P303+P361+P353-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405
- PPE
- Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
- Hazard Codes
- F,Xn
- Risk Statements
- 11 · 11-20/22-36/37/38
- Safety Statements
- 26 · 26-36/37/39
- RIDADR
- 2386 · UN 2386
- WGK Germany
- 1 · 1
- RTECS
- 250000 · TN0250000
- F
- 10 · 10-23
- TSCA
- TSCA listed
- HazardClass
- 3 · 3
- PackingGroup
- II
- HS Code
- 29333990 · 29333990
- Storage Class
- 3 · 3 - Flammable liquids
- Hazard Classifications
- 3 InhalationAcute · Acute Tox. 3 InhalationAcute Tox. 3 OralAcute Tox. 4 DermalEye Dam. 1Flam. Liq. 2Skin Corr. 1B
- REACH Registrations
- Active
- Limited Quantities
- 1 L · 1.0 L (0.3 gallon) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
Safety & regulation
GHS classification
GHS Classification
Danger
H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 213 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Piperidine, 1-ethyl-
Piperidine, 1-ethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Piperidine, 1-ethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 16-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/11076
Piperidine, 1-ethyl-: HSNO Approval: HSR001045 Approved with controls
The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
DOT LabelFlammable Liquid Corrosive
Fire Hazards
Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:
· Flammable/combustible material.
Health Hazards
Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:
· May cause toxic effects if inhaled or ingested.
DOT ID and Guide2386 132
Reactive GroupAmines, Phosphines, and Pyridines
Reactivity AlertsHighly Flammable
Reactivity Profile
1-ETHYLPIPERIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
DOT Hazard Classification
1-Ethylpiperidine
UN2386
Class 3 Flammable and combustible liquid (49 eCFR § 173.120)
Class 3 Flammable and combustible liquid (49 eCFR § 173.120)
PG II: the degree of danger presented by the material is medium
Air and Water ReactionsHighly flammable. Soluble in water.
Hazard Classes and Categories
Flam. Liq. 2 (100%)
Flammable agents - 3rd degree
Safety & protection
Fire FightingExcerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:
Accidental Release Measures
· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.
· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
First Aid
Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:
General First Aid:
Exposure Control and Personal Protection· Wear positive pressure self-contained breathing apparatus (SCBA).
Nonfire Spill ResponseExcerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:
Isolation and Evacuation
Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:
Immediate precautionary measure
Personal Protective Equipment (PPE)Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:
Emergency Response Planning Guidelines· Some of these materials may react violently with water.
Safety data
- F
- 10-23
- PPE
- Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
- wgk
- 1
- tsca
- TSCA listed
- rtecs
- TN0250000
- ridadr
- UN 2386
- hs_code
- 29333990
- risk_code
- 11-20/22-36/37/38
- Signal word
- Danger
- Symbol(GHS)
- GHS02,GHS05,GHS07
- hazard_code
- F,Xn
- safety_code
- 26-36/37/39
- hazard_class
- 3
- Storage Class
- 3 - Flammable liquids
- packing_group
- II
- Hazard statements
- H302+H312+H332-H314-H225
- Limited Quantities
- 1.0 L (0.3 gallon) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 3 InhalationAcute Tox. 3 OralAcute Tox. 4 DermalEye Dam. 1Flam. Liq. 2Skin Corr. 1B
- Precautionary statements
- P501-P261-P270-P240-P210-P233-P243-P241-P242-P271-P264-P280-P370+P378-P362+P364-P303+P361+P353-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405
Chemistry & industry
Uses & manufacturing
U.S. Production2023: 50,000 - <250,000 lb
Industry UsesIntermediate
General Manufacturing Information
All Other Basic Organic Chemical Manufacturing
Piperidine, 1-ethyl-: ACTIVE
Applications
UsesReactant for: Synthesis of multiprotected kanosamine1 Selective acylation in peptide synthesis2Reagent for: Stereoselective aldol condensation reactions for synthesis of β-lactam antibiotics3 Diastereoselective synthesis of aldols4 Crossed Claisen ester condensation5
UsesIn Room temperature phosphorescence of α-bromonaphthalene induced by cyclodextrin in the presence of hexahydropyridine or 1-ethylpiperidine and its application is described. The highest yields of 5-Bromopyrimidine (37%) were obtained by using 1-ethylpiperidine or triethylamine as condensing agent. Tributyltin hydride and 1-ethylpiperidine hypophosphite were mediated intermolecular radical additions to 2, 4, 6-trichlorophenyl vinyl sulfonate.
General DescriptionA colorless liquid with the odor of pepper. Less dense than water. Flash point 66°F. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers69 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]
武汉欣扬瑞和化学科技有限公司153-07155313 15307155313 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
山东中图化工有限公司17864755731 · [email protected]
科瑞迪化学400-821-5857 021-64326257 · [email protected]
衢州明锋化工有限公司0570-3062502 13819002126;13819008176 · [email protected]
淮安嘉目生物科技有限公司0517-83187139 18205232085 · [email protected]
Syntechem Co.,Ltd[email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
阿法埃莎（中国）化学有限公司400-6106006 · [email protected]
广东云星生物技术有限公司0751-18902340975/189023400307 18902340307 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
江苏艾康生物医药研发有限公司025-5885952 15955137747 · [email protected]
上海隆盛化工有限公司58099637 13585536065 · [email protected]
武汉市皇臻生物化工有限公司13795480948 · [email protected]
上海毕楷科技有限公司18516304666
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
杭州云易国科生物科技有限公司18457506494 · [email protected]
斯百全化学（上海）有限公司021-021-021-67601398-809-809-809 15221380277 · [email protected]
上海思域化工科技有限公司86-21-34053660 · [email protected]
赛默飞世尔科技（中国）有限公司800-810-5118 · [email protected]
北京伊诺凯科技有限公司400-810-7969 010-59572699 · [email protected]
上海遐瑞医药科技有限公司+86 21 61551611
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
北京京土恒盛化工科技有限公司00-13911456598 13911456598 · [email protected]
北京环宇世纪化学科技有限公司hysj_bj.com
PT CHEM GROUP LIMITED+86-85511178; +86-85511178 · [email protected]
上海将来实业股份有限公司021-61552785 · [email protected]
安徽科迪达化工有限公司0554-2106669 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
上海麦克林生化科技股份有限公司15221275939 15221275939 · [email protected]
上海嵩爰化工科技有限公司010-1234567 18521000990 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
深圳振强药物研发有限公司+86-0755-66853366 +86-13670046396 · [email protected]
九鼎化学（上海）科技有限公司4009209199 · [email protected]
广东翁江化学试剂有限公司0751-2815987 13927875076 · [email protected]
广东翁江化学试剂有限公司0751-2886766 13927870850 · [email protected]
成都润泽本土化工有限公司028-88469284 18000562381 · [email protected]
上海泛凯生物医药科技有限公司021-33926058 18030239092 · [email protected]
上海西陇生化科技有限公司021-52907766-8042
上海源叶生物科技有限公司13636370518 · [email protected]
上海贤鼎生物科技有限公司021-021-52271985 17721149837 · [email protected]
Shanghai Acmec Biochemical Technology Co., Ltd.+86-18621343501 · [email protected]
Additional notes
DefinitionChEBI: N-ethylpiperidine is a member of piperidines.
Related reactions
79 records
Compound notes
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