Basic information
- CAS
110452-75-0- Standard SMILES
C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@]3(C)[C@H](O)CCC(C)(C)[C@H]3[C@@H](O)[C@@H](OC(=O)CCCN3CCN(C)CC3)[C@]2(C)O1- InChIKey
PAYHDZDDAHVPDU-AFGWWSASSA-N- Molecular formula
- C29H48N2O7
- Average molar mass
- 536.7 g/mol
- Monoisotopic mass
- 536.34615187
Overview
activates adenylate cyclase and inhibits glucose transport in rat adipocytes
Names & identifiers
- Preferred name
- L 858051
- IUPAC
- [(3R,4aS,5R,6R,6aR,10R,10aS,10bR)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] 4-(4-methylpiperazin-1-yl)butanoate
- English name
- L 858051
- Molecular formula
- C29H48N2O7
- Molecular weight
- 536.70062
Names & synonyms
Dmpb-forskolin110452-75-07-Mpb-forskolin7B-ForskolinL 858051L8580517-Desacetyl-7-(gamma-N-methylpiperazino)butyrylforskolinRefChem:151732L-858051[(3R,4aS,5R,6R,6aR,10R,10aS,10bR)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] 4-(4-methylpiperazin-1-yl)butanoate7-beta-(gamma-(N'-Methylpiperazino)-butyryloxy)-7-desacetylforskolinDTXSID40911686
Show more names
[(3R,4Ar,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] 4-(4-methylpiperazin-1-yl)butanoateFL157044(3R,4aS,5R,6R,6aR,10R,10aS,10bR)-3-Ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-naphtho[2,1-b]pyran-5-yl 4-(4-methylpiperazin-1-yl)butanoate1-Piperazinebutanoic acid, 4-methyl-, 3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-5-yl ester, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-3-Ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-naphtho[2,1-b]pyran-5-yl 4-(4-methylpiperazin-1-yl)butanoate
Database identifiers
- CAS
110452-75-0- PubChem CID
- 130638
- DTXSID
DTXSID40911686
Properties
Computed structural properties
- XLogP
- 1.1
- Topological polar surface area
- 120 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 7
- Heavy atoms
- 38
- Formal charge
- 0
- Complexity
- 949
Chemistry & industry
Applications
DescriptionL 858051 activates adenylate cyclase and inhibits glucose transport in rat adipocytes.
UsesL 858051 is an analog of forskolin that activates adenylate cyclase while also having modulatory effects on intracellular cAMP levels, particularly enhancing the CNG current in cardiac myocytes.
Suppliers3 total
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
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Compound notes
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