Sauristolactam
Basic information
- CAS
128533-02-8- Standard SMILES
COc1c(O)cc2c3c(cc4ccccc4c13)N(C)C2=O- InChIKey
WRFZNTLPRUIGKH-UHFFFAOYSA-N- Molecular formula
- C17H13NO3
- Average molar mass
- 279.29 g/mol
- Monoisotopic mass
- 279.08954328
Overview
Sauristolactam has been reported in Saururus chinensis, Goniothalamus australis, and Saururus cernuus with data available.
Names & identifiers
- Preferred name
- Sauristolactam
- IUPAC
- 14-hydroxy-15-methoxy-10-methyl-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),2,4,6,8,12,14-heptaen-11-one
- English name
- sauristolactam
- Molecular formula
- C17H13NO3
- Molecular weight
- 279.29
Names & synonyms
Sauristolactam128533-02-8DTXSID8015592114-hydroxy-15-methoxy-10-methyl-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),2,4,6,8,12,14-heptaen-11-one14-hydroxy-15-methoxy-10-methyl-10-azatetracyclo(7.6.1.02,7.012,16)hexadeca-1(16),2,4,6,8,12,14-heptaen-11-oneRefChem:181523DTXCID90784122-Hydroxy-1-methoxy-5-methyldibenz(cd,f)indol-4(5H)-oneSauristolactam (Saurolactam)2-hydroxy-1-methoxy-5-methyldibenzo[cd,f]indol-4(5H)-oneSaurolactamDibenz[cd,f]indol-4(5H)-one, 2-hydroxy-1-methoxy-5-methyl-
Show more names
Sauristolactam (Synonyms: Saurolactam)
Dibenz(cd,f)indol-4(5H)-one, 2-hydroxy-1-methoxy-5-methyl-CHEMBL512443orb1706661SCHEMBL30595943DFA53302AKOS040742614DA-67430HY-118482
Database identifiers
- CAS
128533-02-8- PubChem CID
- 131002
Properties
Computed structural properties
- XLogP
- 3.1
- Topological polar surface area
- 49.8 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 440
Physicochemical properties
- Melting point
- 276 °C · 276 °C
- Boiling point
- 579 · 579.0±50.0 °C(Predicted)
- Density
- 1.403 · 1.403±0.06 g/cm3(Predicted)
- pka
- 8.75 · 8.75±0.20(Predicted)
Chemistry & industry
Applications
UsesSauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells[1]. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation[2].
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Compound notes
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