Basic information
- CAS
41372-22-9- Standard SMILES
CC(O)C(=O)[O-].CC(O)C(=O)[O-].[Ca+2]- InChIKey
MKJXYGKVIBWPFZ-UHFFFAOYSA-L- Molecular formula
- C6H10CaO6
- Average molar mass
- 218.22 g/mol
- Monoisotopic mass
- 218.01032902
Overview
Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Calcium Lactate...
Names & identifiers
- Preferred name
- Calcium Lactate
- IUPAC
- calcium bis(2-hydroxypropanoate)
- English name
- calcium lactate
- Molecular formula
- C3H6O3.xCa
- Molecular weight
- 0
Names & synonyms
calcium lactate814-80-2CalphosanConclyte calciumHemicalcium L-lactateLactic acid, calcium salt (2:1)2-Hydroxypropanoic acid calcium saltPropanoic acid, 2-hydroxy-, calcium salt (2:1)Ca lactateCalcium lactate anhydrousDTXSID0020236Calcium 2-hydroxypropanoate (1:2)
Show more names
Einecs 227-266-2Calcium 2-hydroxyproprionate EINECSPropanoic acid, 2-hydroxy-, calcium salt2-Hydroxypropanoic acid/calcium,(1:x) salt
Calcium (as lactate)Calcium lactate, anhydrousIns No.3272URQ2N32W3INS-327INS-327-DTXCID60236E-327
Database identifiers
- CAS
41372-22-9、5743-48-6、814-80-2- PubChem CID
- 13144
- DTXSID
DTXSID0020236- ChEMBL
CHEMBL2106111- UNII
- 2URQ2N32W3
- EC Number
Properties
Computed structural properties
- Topological polar surface area
- 121 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 0
- Heavy atoms
- 13
- Formal charge
- 0
- Complexity
- 53.5
Experimental & physicochemical properties
Chemical ClassesMetals -> Metals, Inorganic Compounds
Cosmetics
Cosmetic ingredients (Calcium Lactate) -> CIR (Cosmetic Ingredient Review)
Buffering
pHBetween 6,0 and 8,0 (5 % solution)
Food AdditivesDOUGH STRENGTHENER, FIRMING AGENT, FLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, LEAVENING AGENT, MALTING OR FERMENTING AID, NUTRIENT SUPPLEMENT, PH CONTROL AGENT, STABILIZER OR THICKENER -> FDA Substance added to food
Color/FormWhite, crystalline powder
Solubility
Soluble in water and practically insoluble in ethanol
Almost odorless, slightly efflorescent granules or powder; slowly sol in cold water; quickly sol in water; almost insol in alcohol; becomes anhydrous @ 120 °C; pH: 6-8 /Pentahydrate/
Sol in water
DecompositionWhen heated to decomposition it emits acrid smoke and irritating fumes.
Melting Point> 120
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 3.7% (7 of 191) of reports.
Warning
H319 (96.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)
Aggregated GHS information provided per 191 reports by companies from 3 notifications to the ECHA C&L Inventory.
Warning
Hazard information
Regulatory Information
Chemical: Propanoic acid, 2-hydroxy-, calcium salt (2:1)
Regulation (EC) No 1831/2003 (amended)
Propanoic acid, 2-hydroxy-, calcium salt (2:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propanoic acid, 2-hydroxy-, calcium salt (2:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Cease Manufacture Update: 05-04-2013 https://echa.europa.eu/registration-dossier/-/registered-dossier/11981
Propanoic acid, 2-hydroxy-, calcium salt (2:1): Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Propanoic acid, 2-hydroxy-, calcium salt (2:1): Human health tier I assessment
Hazards SummaryClassified as generally recognized as safe (GRAS) when used in food; [HSDB] May cause irritation; [MSDSonline] See Calcium.
FDA Requirements
Substance added directly to human food affirmed as generally recognized as safe (GRAS).
Calcium lactate used as a general purpose food additive is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Hazard Classes and Categories
Chemistry & industry
Pharmacology
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Protein BindingNo pharmacokinetic data available.
PharmacodynamicsBoth components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively.
Mechanism of Action
In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways. Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis.
Biological Half-LifeNo pharmacokinetic data available.
Metabolism/Metabolites
In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle.
RUMINAL INGESTA FROM COWS FED 2.5 L GRAIN-ALFALFA HAY MIXT PROVIDING 545 G OF SODIUM LACTATE & CALCIUM LACTATE DAILY INCUBATED WITH SODIUM LACTATE OR 17 POLY LACTIC ACID. ACETATE WAS PRIMARY END PRODUCT BUT OXIDN OF LACTATE CAUSED SYNTH OF BUTYRATE FROM ACETATE.
Absorption, Distribution and Excretion
In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins. The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport.
Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours.
Related reactions
14 records
Compound notes
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