Methoprotryne

Extinguish fire using agent suitable for type of surrounding fire. ... Use water in flooding quantities as fog. Use "alcohol foam" ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Triazine pesticide (compounds and preparations), solid (insecticides, agricultural, not elsewhere classified, other than liquid)/

Avoid breathing dusts & fumes from burning material. Keep upwind. /Triazine pesticide, solid, not otherwise specified, (compounds and preparations), (agricultural insecticides, not elsewhere classified, other than liquid)/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Noncombustible containers should be crushed & buried under more than 40 cm of soil. /Herbicides/

Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/

Group II Containers: Noncombustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/

Avoid contact with eyes, contact with skin, inhalation of dust, & contamination of food & feed.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. /Triazine pesticide, solid, not otherwise specified (compounds and preparations), (agricultural insecticides, not elsewhere classified, other than liquid)/ Not elsewhere classified.

Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Triazine pesticide, solid, not otherwise specified (compounds and preparations), (agricultural insecticides, not elsewhere classified, other than liquid)/

LC50 BLUEGILL 15.5 MG/L/96 HR @ 18 °C (95% CONFIDENCE LIMIT 13.9-17.2 MG/L), WT 0.9 G STATIC BIOASSAY

LC50 Bluegill 9.8 mg/l/96 hr /Conditions for assay not given/

LC50 Rainbow trout 8 mg/l/96 hr /Conditions for assay not given/

LC50 Crucian carp 31 mg/l/96 hr /Conditions for assay not given/

TERRESTRIAL FATE: ... TRIAZINES ... ARE NOT READILY DEGRADED BY SOIL MICROORGANISMS. THUS, THEIR RATE OF DECAY IS RELATIVELY SLOW, & AS THESE MATERIALS ALSO DO NOT READILY LEACH FROM THE SOIL, THEY MAY PERSIST FOR QUITE EXTENDED PERIODS OF TIME. /TRIAZINES/

TERRESTRIAL FATE: If methoprotryne is released to soil, it will be expected to exhibit moderate mobility based upon(1) a Koc estimated(5,SRC) using water solubility(4) and, therefore, it may leach to groundwater. It may be susceptible to slow hydrolysis in soil(2,3). Volatilization from near-surface soil is not expected to be an important removal mechanism(SRC). It is unknown whether methoprotryne will biodegrade in soil(SRC).

AQUATIC FATE: If released to water, methoprotryne will not be expected to bioconcentrate in aquatic organisms, adsorb to sediment and suspended particulate matter, or to volatilize. Methoprotryne may be susceptible to slow hydrolysis in water(2) and photooxidation by photochemically produced hydroxyl radicals(1) in water, based upon data for s-triazine herbicides with similar structures to methoprotryne such as prometryn(1,2). It is unknown whether methoprotryne will biodegrade in natural waters(SRC).

ATMOSPHERIC FATE: If methoprotryne is released to the atmosphere, it may be subject to gas-phase reaction with hydroxyl radicals with a half-life of about 2.4 hr estimated for this process(1).

TERRESTRIAL FATE: THE LONG SOIL PERSISTENCE OF THESE CMPD DOES ... CREATE THE PROBLEM OF SOIL CARRY OVER, WHICH CAN DAMAGE SUCCEEDING CASH CROPS. THEREFORE EXTREME CAUTION MUST BE TAKEN IN THEIR APPLICATION ON CROPLAND TO AVOID SUCH INJURY TO FOLLOWING CROPS. /TRIAZINES/

Preliminary medical exam to detect chronic diseases of CNS, liver, heart, kidneys, lungs & skin, as well as endocrinological or immunological disturbances, should ... /protect/ susceptible individuals. ... Periodical medical exam of internal organs, skin & eyes is important to avoid chronic occupational intoxications. It should include lab tests & patch tests if necessary. /Herbicides/

ADSORPTION OF TRIAZINES THROUGH EXCHANGE PROCESS TO ORGANIC MATTER & CLAY MINERALS IS DEPENDENT ON PH OF SOLN & ACIDITY OF ADSORBENT SURFACE. HYDROGEN BONDING & HYDROPHOBIC BONDING ARE OTHER MECHANISMS BY WHICH SOIL ORGANIC MATTER ADSORBS TRIAZINE HERBICIDES, ESP AT HIGHER PH LEVELS. ... TRANSPORT FROM SOIL TO WATER OCCURS IN SOLUTION & IN SEDIMENTS. /TRIAZINE HERBICIDES/

Based upon a water solubility of 320 ppm at 20 degC(3), a Koc of 180 has been estimated(4). Based upon this estimated Koc, methoprotryne will be expected to exhibit medium mobility in soil(5). Evidence has been reported which indicates that the basicity of s-triazine herbicides, such as methoprotryne, is not the main factor governing adsorption to soil humic acids(1). It has been shown that the ability of s-triazines herbicides to act as electron donors to electron acceptor quinone-like units of humic acids also plays an important role in the adsorption(2).

Vapor transport losses of triazines are dependent on vapor pressure & pH of evaporating surface, since ionized cmpd are less volatile. /Triazine herbicides/

Based upon a water solubility of 320 mg/l at 20 °C(1) and a vapor pressure of 2.85X10-7 mm Hg at 20 °C(1), the Henry's Law constant for methoprotryne of 3.18X10-10 atm-cu m/mole can be calculated(2,SRC). This value of Henry's Law constant indicates volatilization of methoprotryne will not be environmentally important(2).

In 90 day feeding trials, no effect level was: for rats 3750 mg active ingredient/kg diet (about 250 mg active ingredient/kg daily); for dogs 11,250 mg/kg diet (about 375 mg/kg daily).

Maize seeds (Zea mays) were germinated in Linhardt dishes to which the following herbicides: 2,4-D, dicamba, Icedin, Igran and Gesaran were added. The concentration of herbicides was similar to those used against various weeds. The tips of primary roots of 4-, 5- ad 7-day-old seedlings were cut and nuclear DNA was Feulgen stained. The relative amount of nuclear DNA was measured. The research showed that the 5 herbicides can produce significant variations in the amount of nuclear DNA depending on the nature of herbicide used. These variations may be related to the changes in the cell cycle of root meristems under the influence of herbicides.

In soil ... cleavage of the thiomethyl group and replacement with hydroxyl /occurs/, presumably after oxidation of the sulfur to sulfoxide and sulfone. Demethylation of the amino groups at C4 and C6, cleavage of the amine moieties and their replacement by hydroxyl, presumably followed by ring opening.

The rate constant for the vapor-phase reaction of prometryn with photochemically produced hydroxyl radicals has been estimated to be 161.9 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of about 2.4 hr at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1). Methoprotryne may be susceptible to slow hydrolysis in water or soil(3), and photooxidation by photochemically produced hydroxyl radicals(4), based upon data for s-triazine herbicides with similar structures with methoprotryne such as prometryn(3,4). The rate of hydrolysis may be increased by various catalysts based upon the observed increase in rate of hydrolysis rates for the chemically similar herbicide atrazine in water solutions upon addition of sterilized soil(5) and humic(6) and fulvic acids(2).