HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-2-pyrrolidone
NMP · N-METHYLPYRROLIDONE · 1-methyl-pyrrolidin-2-one · 1-METHYL-2-PYRROLIDINONE · 1-METHYL-2-PYRROLIDONE · 1-Methylpyrrolidin-2-one · N-METHYL-2-PYRROLIDINONE · N-METHYLPYRROLIDINONE
Identifiers & Physical Properties
| CAS No. | 30207-69-3 |
|---|---|
| Molecular formula | C5H9NO |
| Average molar mass | 99.13 g/mol |
| Monoisotopic mass | 99.06841391 g/mol |
| SMILES | CN1CCCC1=O |
| InChIKey | SECXISVLQFMRJM-UHFFFAOYSA-N |
| PubChem CID | 13387 |
| ChEMBL | CHEMBL12543 |
| ChEBI | CHEBI:7307 |
| EC No. | 212-828-1 |
| DTXSID | DTXSID6020856 |
Chemical & Physical Properties
| XLogP | -0.5 |
|---|---|
| Topological polar surface area | 20.3 |
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 1 |
| Rotatable bonds | 0 |
| Heavy atoms | 7 |
| Formal charge | 0 |
| Complexity | 90.1 |
| Chemical classes | TeratogensIndustrial compound |
| Drugs | Pharmaceuticals -> Listed in ZINC15 |
| Solvents | Solvents -> Other Solvents |
| Cosmetics | Surfactant |
| pH | pH = 7.7-88.5-10.0 (100g/l, H2O, 20℃) |
| SpringerMaterials Properties | 15N nuclear magnetic resonance spectrum |
| LogP (partition coefficient) | log Kow = -0.38-0.54 |
| Odor | Mild amine odorSlight amine odor |
| Density | 1.03 at 77 °F (USCG, 1999) - Denser than waterwill sink1.027 at 25 °C/25 °CRelative density (water = 1): 1.031.027 @25 °C1.028 g/mL at 25 °C (lit.) |
| Viscosity | 1.65 cP at 25 °C1.62 mm²/s at 25 °C |
| Color/Form | Clear liquid |
| Solubility | greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)Miscible with water, alcohol, ether, acetone, ethyl acetate, chloroform, benzeneMiscible with castor oilMiscible with lower alcohols and ketonesModerately soluble in aliphatic hydrocarbons and dissolves many organic and inorganic compounds.Solubility in water: miscibleethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)>=10 g/100 mL at 20 ºC |
| Melting point | -24 °C (lit.) |
| Boiling point | 202 °C (lit.) 81-82 °C/10 mmHg (lit.) |
| Vapor density | 3.4 (vs air) |
| Vapor pressure | 0.29 mm Hg ( 20 °C) |
| Refractive index | n20/D 1.479 |
| Flash point | 187 °F |
| Storage conditions | Store at +5°C to +30°C. |
| Physical state | Liquid |
| pKa (acidity coefficient) | -0.41±0.20(Predicted) |
| Color | ≤20(APHA) |
| PH Range | 7.7 - 8.0 |
| Explosive limits | 1.3-9.5%(V) |
| Thermal conductivity | 0.162 W/(m·K) at 25 ℃ |
| Specific heat capacity | Cp(liquid): 3.11 J/(g·K), at 25℃ |
| λmax | 283nm(MeOH)(lit.) |
| Sensitivity | Hygroscopic |
| Merck | 14,6117 |
| BRN | 106420 |
| Henry's law constant | 3.1×103 mol/(m3Pa) at 25℃, Brockbank (2013) |
| Exposure limits | EU LTEL: 10 ppm(40 mg/m3)EU STEL: 20 ppm(80 mg/m3) |
| Dielectric constant | 32.200000000000003 |
| Stability | Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases. |
| Major applications | food and beverages |
| Cosmetics Ingredients Functions | SOLVENT |
| InChI | 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3 |
| InChIKey | SECXISVLQFMRJM-UHFFFAOYSA-N |
| SMILES | CN1CCCC1=O |
| LogP (partition coefficient) | -0.46 at 25℃ |
| Surface tension | 41.3mN/m at 293.15K |
| Substances of Very High Concern (SVHC) Candidate List | 1-Methyl-2-pyrrolidone (NMP) (872-50-4) |
| REACH Annex XVII Substances List | 1-methyl-2-pyrrolidone (872-50-4) |
| FDA 21 CFR | 176.300177.1655177.2440 |
| Indirect Additives used in Food Contact Substances | N-METHYL-2-PYRROLIDONE |
| CAS DataBase Reference | 872-50-4(CAS DataBase Reference) |
| FDA UNII | JR9CE63FPM |
| Proposition 65 List | N-Methylpyrrolidone |
| NIST Chemistry Reference | 2-Pyrrolidinone, 1-methyl-(872-50-4) |
| EPA Substance Registry System | N-Methyl-2-pyrrolidone (872-50-4) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
| GHS pictogram | GHS07,GHS08 |
| Signal word | Danger |
| GHS hazard statements | H315-H319-H335-H360D |
| GHS precautionary statements | P202-P261-P264-P302+P352-P305+P351+P338-P308+P313 |
| Target organs | Respiratory system |
| Hazard symbols | T,Xi |
| Risk statements (R) | 45-65-36/38-36/37/38-61-10-46 |
| Safety statements (S) | 41-45-53-62-26 |
| UN transport number | NA1993 |
| Water hazard class (WGK) | 1 |
| RTECS number | UY5790000 |
| F | 3-8-10 |
| Autoignition temperature | 518 °F |
| TSCA inventory status | TSCA listed |
| Hazard class | CBLEye Irrit. 2Repr. 1BSkin Irrit. 2STOT SE 3 |
| Customs code | 2933199090 |
| Storage class | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
| Hazardous substances data | 872-50-4(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg |
| REACH registrations | Active |
| Excepted quantities | Non-Hazardous |
Safety & Regulations
| GHS classification | DangerH315: Causes skin irritation [Warning Skin corrosion/irritation]P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2679) of reports.H315 (> 99.9%): Causes skin irritation [Warning Skin corrosion/irritation] |
|---|---|
| Regulatory information | Chemical: 2-Pyrrolidinone, 1-methyl-Hazard Traits - Developmental ToxicityReproductive ToxicityCouncil Directive (EEC) No 109/1989 (Repealed by Reg. EC No 1935/2004 (amended))2-Pyrrolidinone, 1-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Pyrrolidinone, 1-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 28-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15493Restricted substance: 1-methyl-2-pyrrolidone |
| Other safety information | IMAP assessments - 2-Pyrrolidinone, 1-methyl-: Human health tier III assessment |
| DOT label | Combustible Liquid |
| Fire hazards | Special Hazards of Combustion Products: Toxic oxides of nitrogen may be formed in fire. (USCG, 1999)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 86 °C explosive vapour/air mixtures may be formed. |
| Fire potential | Combustible when exposed to heat, open flame, or powerful oxidizers. |
| Health hazards | Inhalation of hot vapors can irritate nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes causes irritation. Repeated and prolonged skin contact produces a mild, transient irritation. (USCG, 1999) |
| Hazards summary | It is absorbed through the skina severe eye irritant[CSH, p. 291] It is mainly an irritant, but it can cause severe contact dermatitis due to prolonged contact. [Kanerva, p. 1816] Experimental animals experience lethargy and respiratory difficulty after inhalation. [HSDB] Some animal studies found fetal loss and birth defects after high doses during early pregnancy. [Frazier, p. 345] NMP is a cyclic amide used as a solvent, catalyst, formulating agent, and graffiti remover. Significant absorption occurs through the skin. 2-HMSI can be used for biological monitoring of workers. [Akesson B, Carnerup MA, Jonsson BAG. Evaluation of exposure biomarkers from percutaneous absorption of N-methyl-2-pyrrolidone. Scand J Work Environ 200430(4):306-312] In high-dose animal studies, adverse effects include CNS depression and changes to the liver, kidneys, and blood cells. [ACGIH] A skin and eye irritant[ICSC] Danger of cutaneous absorption[AIHA] |
| Reactive group | Amides and Imides |
| EC classification | R: 61-36/37/38S: 53-45 |
| Special Reports | Bower DBJournal of Occupational and Environmental Medicine 39 (5): 393-4 (1997). Stillbirth after exposure to N-methyl-2-pyrrolidone.Solomon GM et alJournal of Occupational and Environmental Medicine 38 (7): 705-13 (1996). Stillbirth after occupational exposure to n-methyl-2-pyrrolidone. A case report and review of the literature.Akesson BArbetsmilj"oinstitutet, F"orlagstj"anst 171 (84): 24 (1994). The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals - N-Methyl-2-pyrrolidone.Wallen MNord 6: 75-89 (1992). Health effects of selected chemicals: methylpyrrilidinone.Lee KP et alFundam Appl Toxicol 9 (2):222-35 (1987). Toxicity of N-methyl-2-pyrrolidone teratogenic subchronic and two-year inhalation study. |
| TSCA requirements | A testing consent order is in effect for N-methylpyrrolidone for health effects testing. FR citation: 11/23/93. |
| FIFRA requirements | Residues of n-methylpyrrolidone are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only. Use: solvent, cosolvent. |
| Fire fighting | Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:Use water spray, powder, alcohol-resistant foam, carbon dioxide. |
| First aid measures | Fresh air, rest. Refer for medical attention.Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer for medical attention . |
| First aid | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Safe storage | Dry. Ventilation along the floor. Separated from strong oxidants, strong acids, strong bases, copper and plastics. |
| Exposure control and personal protection | Biological Exposure Indices (BEI) [ACGIH] - 5-Hydroxy-N-methyl-2-pyrrolidone in urine = 100 mg/L at end of shift20.0 [ppm], (can also occur as vapor and aerosol)[German Research Foundation (DFG)] |
| Fire fighting procedures | Use water spray, powder, alcohol-resistant foam, carbon dioxide. |
| Storage conditions | Small quantities can be stored in polyethylene, polypropylene, or clear glass bottles.Safe Storage: Separated from oxidants, rubber, plastics, aluminum and light metals. Dry. Ventilation along the floor. |
| Cleanup methods | Spillage Disposal: Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
| Nonfire spill response | SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Disposal methods | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations. |
| Spillage disposal | Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb liquid in sand or inert absorbent. Store and dispose of according to local regulations. Wash away remainder with plenty of water. |
| Preventive Measures | Do not eat, drink, or smoke during work.SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
| Interactions | The ability of N-methylpyrrolidone and polar lipids to increase the percutaneous delivery of metronidazole was investigated across full thickness human nonoccluded skin in vitro. Fatty acids and ethyl alcohol were also tested and were effected in penetration enhancement in propylene glycol vehiclesN-methylpyrrolidone increased metronidazole penetration from isopropyl myristate vehicles but not from propylene glycol. N-methylpyrrolidone premeated skin readily when applied in the neat state or in a mixture with isopropyl myristate. Results indicated that variations in barrier permeability to metronidazole were associated with the rate of N-methylpyrrolidone permeating the skin.The effect of a penetration enhancer, N-methylpyrrolidone (N-methyl-2-pyrrolidone) or isopropyl myristate, on the in vitro permeability of gonadorelin (luteinizing hormone-releasing hormoneLHRH) through porcine epidermis was investigated. The permeability coefficient of gonadorelin significantly increased through penetration enhancer treated epidermis in comparison to the control. It was concluded that both penetration enhancers can enhance the percutaneous absorption of peptides such as gonadorelin.Laurocapram (Azone1-dodecylazacycloheptan-2-oneI), N-methylpyrrolidone (N-methyl-2-pyrrolidoneII) and dodecyl-L-pyroglutamate (III) were studied in permeation cells in vitro, for their ability to improve the absorption of insulin (IV) and FD&C Blue No. 1 (brilliant blue FCFV) through skinthe compounds were formulated into a 40% solution of propylene glycol in increasing concentrations. ... The permeation of V was improved in the presence of II, with concentrations of II ranging from 6.0 to 20.0% exhibiting the same efficacy. In experiments with IV, the optimum efficacy of II was found at a concentration close to 10.0%, with a decline in efficacy in higher and lower concentrations. ... |
| Ecotoxicity values | LC50Species: Daphnia magna (Water Flea) age <24 hrConditions: freshwater, static, 23 °C, pH 7, dissolved oxygen 7.8 mg/LConcentration: 2500 ug/L for 24 hr (95% confidence interval: 1800-3500 ug/L) />99.9% purity/Concentration: 1230 ug/L for 48 hr (95% confidence interval: 1000-1500 ug/L) />99.9% purity/ |
| Environmental fate | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 4.3(SRC), determined from a log Kow of -0.38(2) and a regression-derived equation(3), indicates that 1-methyl-2-pyrrolidone is expected to have very high mobility in soil(SRC). Volatilization of 1-methyl-2-pyrrolidone from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 3.20X10-9 atm-cu m/mole(4). 1-Methyl-2-pyrrolidone is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.345 mm Hg at 25 °C(5). Utilizing the Japanese MITI test, 73% of the Theoretical BOD was reached in 4 weeks(6) indicating that biodegradation is an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 4.6(SRC), determined from a log Kow of -0.38(2) and a regression-derived equation(3), indicates that 1-methyl-2-pyrrolidone is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon a Henry's Law constant of 3.20X10-9 atm-cu m/mole(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 73% of the Theoretical BOD was reached in 4 weeks(7) indicating that biodegradation is an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-methyl-2-pyrrolidone, which has a vapor pressure of 0.345 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-methyl-2-pyrrolidone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 5.2 hrs(SRC), calculated from its rate constant of 7.40X10-11 cu cm/molecule-sec at 25 °C(3). 1-Methyl-2-pyrrolidone does not absorb light at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). |
| Food survey values | 1-Methyl-2-pyrrolidinone has been detected as a volatile flavor component of roasted filberts(1). |
| Adverse effects | Neurotoxin - Acute solvent syndrome |
| Exposure routes | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
| Signs and Symptoms | Headache.MAY BE ABSORBED! Redness. Pain.Redness. Pain. Blurred vision.Burning sensation in the throat and chest.Rapid, irregular respiration, shortnessof breath, decreased pain reflex, and slight bloody nasalsecretion. |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of October 25, 2012: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=872-50-4] |
| Effluent Concentrations | 1-Methyl-2-pyrrolidinone was detected in 1 of 46 US industrial effluent samples(1). 1-Methyl-2-pyrrolidone is present in shale oil retort water(2,3). 1-Methyl-2-pyrrolidinone was found in shale retort water at a concentration of 3 mg/L(2). Retort Water Treatment Cell analysis showed an influent concentration of 2.8 and effluent concentrations of not detected, 1.4, 3.3, and 10.1 mg/L at 1, 3, 5 and 7 weeks of treatment cell operation, respectively, suggesting a desorption from solids over time(3). The compound was detected at concentrations of 66.3 and 33.7 ug/L in wastewaters from a petrochemical plant sampled in January and March 1997, respectivelyit was not detected in a July 1996 sample. 1-Methyl-2-pyrroldinone was detected at concentrations of 0.2 and 3.9 ug/L in leachate from an industrial landfill sampled in December 1996 and March 1997, respectivelylocations not specifiedlimit of detection was 0.2 ug/L(4). 1-Methyl-2-pyrrolidinone was detected at 68.9 ug/L in leachate from a municipal waste landfill in Japan(5).1-Methyl-2-pyrrolidinone was detected in the raw effluent from a textile finishing plant, North Carolina, concentration not provided(1). The compound was detected in spraybooth scrubber automotive painting operation at a concentration of 300 mg/L of boothwater, 1.51X10-8 ar partial pressure, atm in airthe compound was applied in spray at 7700 kg/annum(2). |
| Soil Adsorption/Mobility | The Koc of 1-methyl-2-pyrrolidone is estimated as 5(SRC), using a log Kow of -0.38(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1-methyl-2-pyrrolidone is expected to have very high mobility in soil. 1-Methyl-2-pyrrolidinone had Rf values of 0.74, 0.65, 0.67, and 1.0 in silt, loam, clay and sand, respectively, in laboratory soil thin layer chromatography (TLC) experiments(4) which is consistent with significant mobility in soil(SRC). |
| Atmospheric Concentrations | INDOOR AIR: 1-Methyl-2-pyrrolidinone was detected at 142 ug/cu m (waterborne system) from furniture that had been coated in a wood preservative mixture(1). |
| Human Toxicity Excerpts | /HUMAN EXPOSURE STUDIES/ Six male volunteers were exposed for eight hours on four different days to 0, 10, 25, and 50 mg/cu m N-methyl-2-pyrrolidone. Plasma was collected and urine was sampled during and after the exposure. Changes in nasal volume were measured by acoustic rhinometry and in airway resistance by spirometry. The eight-hour experimental exposure to 10, 25, and 50 mg/cu m did not induce discomfort to eyes or upper airways. Acute changes in nasal volume were not found, and no changes in the spirometric data could be registered. ... N-Methyl-2-pyrrolidone was absorbed through the respiratory tract and readily eliminated from the body, mainly by biotransformation to other compounds. Exposure to 10, 25, or 50 mg/cu m N-methyl-2-pyrrolidone did not cause nose, eye, or airway irritation. Thus, N-methyl-2-pyrrolidone is a mild irritant./SIGNS AND SYMPTOMS/ It can cause dermatitis with blistering, edema, and erythema with prolonged or repeated contact./SIGNS AND SYMPTOMS/ In the semiconductor industry, headaches and chronic eye irritation were described in some employees exposed to levels as low as 0.7 ppm. Levels of 49 to 83 ppm were found unbearable by the workers./SURVEILLANCE/ Several workers in a small electrotechnical company in Norway experienced irritant reaction of the skin after a few days of working with the solvent N-methyl-2-pyrrolidone. ... After 2 days of work with N-methyl-2-pyrrolidone, 10 of the 12 involved workers displayed acute irritant contact dermatitis of the hands. .../ALTERNATIVE and IN VITRO TESTS/ The effects of absorption enhancers such as laurocapram (Azone), N-methylpyrrolidone, propylene glycol, and oleic acid on the percutaneous absorption of heparin sodium through excised human skin were investigated. Laurocapram, N-methylpyrrolidone, and propylene glycol promomted heparin flux, while oleic acid did not. |
| F | 3-8-10 |
| Water hazard class (WGK) | 1 |
| TSCA inventory status | TSCA listed |
| RTECS number | UY5790000 |
| UN transport number | NA1993 |
| Customs code | 2933199090 |
| Toxicity | LD50 orally in Rabbit: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg |
| Risk statements (R) | 45-65-36/38-36/37/38-61-10-46 |
| Signal word | Danger |
| GHS pictogram | GHS07,GHS08 |
| Hazard symbols | T,Xi |
| Safety statements (S) | 41-45-53-62-26 |
| Hazard class | CBLEye Irrit. 2Repr. 1BSkin Irrit. 2STOT SE 3 |
| Storage class | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
| Target organs | Respiratory system |
| GHS hazard statements | H315-H319-H335-H360D |
| Excepted quantities | Non-Hazardous |
| REACH registrations | Active |
| Autoignition temperature | 518 °F |
| GHS precautionary statements | P202-P261-P264-P302+P352-P305+P351+P338-P308+P313 |
| Hazardous substances data | 872-50-4(Hazardous Substances Data) |
Applications & Uses
Uses
N-Methyl-2-pyrrolidone (NMP) is a polar aprotic solvent that has the advantages of low toxicity, high boiling point, outstanding solvency, strong selectivity and good stability. It is widely used in purification of aromatic hydrocarbon extraction, acetylene, olefins, and diolefins.It is used in industrial cleaning, and it serves as a solvent for production of pesticides, engineering plastics, coatings, synthetic fibers, and integrated circuits.It can also be used as an industrial cleanser, dispersant, dye, lubricant and antifreeze.N-Methyl-2-pyrrolidone is an excellent solvent, widely used in aromatics extraction, lubricating oil refining, acetylene enrichment, butadiene separation and synthesis gas desulfurization.It is used in gas desulfurization, lubricating oil refining, lubricating oil antifreeze, olefin extraction, and as a solvent for insoluble engineering plastics polymerization.It can be used in herbicide, to clean insulation materials, semiconductor industry precision instruments and circuit boards, to recycle PVC exhaust, as a detergent, dye supplement and dispersing agent.It is used in mediums for polymerization reactions such as engineering plastics and aramid fiber.N-Methyl-2-pyrrolidone is used as a polyvinylidene fluoride solvent and electrode auxiliary material for lithium ion batteries.high purity grade for ICP-MS detection.For peptide synthesis.
Description
N-Methyl-2-pyrrolidone is an aprotic solvent with a wide range of applications: petrochemical processing, surface coating, dyes and pigments, industrial and domestic cleaning compounds, and agricultural and pharmaceutical formulations. It is mainly an irritant, but has also caused several cases of contact dermatitis in a small electrotechnical company.
Uses
Solvent for high-temperature resins; petrochemical processing, in the microelectronics fabrication industry, dyes and pigments, industrial and domestic cleaning compounds; agricultural and pharmaceutical formulations
Uses
N-Methyl-2-pyrrolidone, is useful for spectrophotometry, chromatography and ICP-MS detection.
Uses
N-Methyl-2-pyrrolidone is a polar solvent that is used in organic chemistry and polymer chemistry. Large scale applications include the recovery and purification of acetylenes, olefins, and diolefins, gas purification, and aromatics extraction from feedstocks.N-Methyl-2-pyrrolidone is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.
General Description
N-Methyl-2-Pyrrolidone (NMP) is a powerful, aprotic solvent with high solvency, and low volatility. This colorless, high boiling, high flash point and low vapor pressure liquid carries a mild amine-like odor. NMP has high chemical and thermal stability and is completely miscible with water at all temperatures. NMP can serve as a co-solvent with water, alcohols, glycol ethers, ketones, and aromatic/chlorinated hydrocarbons. NMP is both recyclable by distillation and readily biodegradable. NMP is not found on the Hazardous Air Pollutants (HAPs) list of the 1990 Clean Air Act Amendments.