CAS 24666-56-6 3-Aminopiperidine-2,6-dione hydrochloride (HCID 134548)

Names & identifiers

Preferred name: 3-Aminopiperidine-2,6-dione hydrochloride
IUPAC: 3-aminopiperidine-2,6-dione;hydrochloride
English name: 2,6-Dioxopiperidine-3-ammonium chloride
Molecular formula: C5H9ClN2O2
Molecular weight: 164.59016

Names & synonyms

3-aminopiperidine-2,6-dione hydrochlorideRefChem:497763806-697-5807-866-624666-56-62686-86-43-Amino-2,6-piperidinedione hydrochloride2,6-dioxopiperidine-3-ammonium chloride3-aminopiperidine-2,6-dione HClMFCD110424372,6-Piperidinedione, 3-amino-, hydrochloride (1:1)3-aminopiperidine-2,6-dione;hydrochloride

Show more names

2,6-dioxopiperidin-3-aminium chloridePomalidomide Impurity 62,6-Dioxopiperidine-3-ammoniumRSYY（Avanafil)-31Lenalidomide/PomadoamineLenalidomide EP Impurity-ALenalidomide Impurity 6 HClLenalidomide Impurity 9 HClLenalidomide Impurity 2 HCl

3-amino-piperidine-2,6-dione hydrochloride3-amino-aza-cyclohexane 2,6-dione hydrochloride2,6-Piperidinedione, 3-amino-, monohydrochloride3-Aminopiperidine-26-dione hydrochloride3-amino piperdine-2,6-dion hydrochlorideC5H9ClN2O2alpha-amino glutarimide hydrochlorideGlutamic acid imide hydrochloride

Database identifiers

CAS: 24666-56-6、2686-86-4
PubChem CID: 134548
DTXSID: DTXSID60947609
UNII: V22J5M2KYT
EC Number: 806-697-5、807-866-6

Properties

Computed structural properties

Topological polar surface area: 72.2 Å²
Hydrogen bond donors: 3
Hydrogen bond acceptors: 3
Rotatable bonds: 0
Heavy atoms: 10
Formal charge: 0
Complexity: 155

Physicochemical properties

Melting point: 120 °C · 120 °C (approx)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Sparingly, Sonicated)
form: powder
color: White
InChI: InChI=1S/C5H8N2O2.ClH/c6-3-1-2-4(8)7-5(3)9;/h3H,1-2,6H2,(H,7,8,9);1H
InChIKey: YCPULGHBTPQLRH-UHFFFAOYSA-N
SMILES: C1CC(N)C(=O)NC1=O.Cl
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 271 · P271-P261-P280
Risk Statements: 20 · 20/21/22
Safety Statements: 3 · 3/9-36/37
HS Code: 29339900 · 29339900

Safety & regulation

GHS classification

GHS Classification · 6 items

Warning

H302 (71.4%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 7 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

Hazard information

Hazard Classes and Categories · 2 items

Skin Irrit. 2 (100%)

Acute Tox. 4 (71.4%)

Safety data

hs_code: 29339900
risk_code: 20/21/22
Signal word: Warning
Symbol(GHS): GHS07
safety_code: 3/9-36/37
Hazard statements: H315-H319-H335
Precautionary statements: P271-P261-P280

Chemistry & industry

Applications · 2 items

Description2,6-Dioxopiperidine-3-ammonium chloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del (5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation. Moreover, it is also a metabolite of thalidomide (T338850) that inhibits FGF-induced angiogenesis.

Uses2,6-Dioxopiperidine-3-ammonium chloride can be used as an important intermediate of antineoplastic drug lenalidomide.