Eltrombopag olamine

HCID 135449331

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Basic information

CAS: 496775-62-3
Standard SMILES: Cc1ccc(-n2[nH]c(C)c(N=Nc3cccc(-c4cccc(C(=O)O)c4)c3O)c2=O)cc1C.NCCO.NCCO
InChIKey: DJMJHIKGMVJYCW-UHFFFAOYSA-N
Molecular formula: C29H36N6O6
Average molar mass: 564.6 g/mol
Monoisotopic mass: 564.26963289

Overview

Eltrombopag olamine is an organic molecular entity.

Names & identifiers

Preferred name: Eltrombopag olamine
IUPAC: bis(2-aminoethanol);3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid
English name: Eltrombopag Olamine
Molecular formula: C27H29N5O5
Molecular weight: 503.56

Names & synonyms

Eltrombopag olamine496775-62-3PromactaRevoladeUNII-4U07F515LGEltrombopag (Olamine)SB-497115-GRPromacta (TN)Eltrombopag (as olamine)MFCD223806644U07F515LGEltrombopag compd with 2-aminoethanol (1:2)

Show more names

Eltrombopag DiolamineEltrombopag OlaminEltroMbopag IMpurityEltroMbopag OlaMine APIEltrombopag ethanolamineSb 497115grUnii-4U07F515ELTROMBOPAG OL

Eltrombopag diethanolamine salt;SB-497115GR2-Aminoethan-1-ol hemi((Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate)C29H36N6O62-aminoethan-1-ol hemi((Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate)2-aminoethanol;3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid3'-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)496775-62-3 (olamine)Eltrombopagolamine

Database identifiers

Properties

Computed structural properties

Topological polar surface area: 207 Å²
Hydrogen bond donors: 7
Hydrogen bond acceptors: 11
Rotatable bonds: 7
Heavy atoms: 41
Formal charge: 0
Complexity: 822

Physicochemical properties

storage temp.: 2 · under inert gas (nitrogen or Argon) at 2–8 °C
solubility: 56.33 · DMSO:56.33(Max Conc. mg/mL);99.76(Max Conc. mM)DMF:1.0(Max Conc. mg/mL);1.77(Max Conc. mM)DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.44(Max Conc. mM)Ethanol:0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
form: Powder
color: Purple to black
Stability: Hygroscopic
InChIKey: LQQUHOUXABUDJA-OUFJFOJPSA-N
SMILES: C(N)CO.O=C1/C(/C(C)=NN1C1C=CC(C)=C(C)C=1)=N\NC1C=CC=C(C2C=CC=C(C(=O)O)C=2)C=1O
NCI Dictionary of Cancer Terms: eltrombopag olamine
FDA UNII: 4 U07F515LG · 4U07F515LG
NCI Drug Dictionary: eltrombopag olamine
NACRES: 21 · NA.21
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 319 · H319-H412
Precautionary statements

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

Safety data

Signal word: Warning
Symbol(GHS): GHS07
Hazard statements: H319-H412
Precautionary statements: P264-P280-P305+P351+P338-P337+P313P-P273-P501

Chemistry & industry

Applications · 2 items

DescriptionEltrombopag Olamine is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. It has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C.

UsesTreatment of chemotherapy-induced thrombocytopenia and treatment of immune thrombocytopenic purpura.

Suppliers100 total

山东雨禾医药科技有限公司15263077727 · [email protected]

Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]

上海波以尔化工有限公司[email protected]

成都伊诺达博医药科技有限公司15620227207 · [email protected]

上海柯维化学技术有限公司021-64609169 18901607656 · [email protected]

Related reactions

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Compound notes

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