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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 135483987Generated: October 23, 2026

6-hydroxy-1H-indazole

1H-indazol-6-ol · 6-Hydroxy-1H-indazole · 6-Indazolol · indazol-6-ol · 6-hydroxyindazole · 6-Hydroxy-1H-indazoL · 6-Hydroxyindazole>1,2-dihydroindazol-6-one · 1H-Indazol-6-ol (6CI, 8CI, 9CI, ACI)

https://huagongshe.com/en/chemical/135483987

6-hydroxy-1H-indazole molecular structure

Identifiers & Physical Properties

CAS No.23244-88-4
Molecular formulaC7H6N2O
Average molar mass134.14 g/mol
Monoisotopic mass134.04801281 g/mol
SMILESOc1ccc2cn[nH]c2c1
InChIKeyNUYZVDBIVNOTSC-UHFFFAOYSA-N
PubChem CID135483987
EC No.245-519-5
DTXSIDDTXSID70901318

Chemical & Physical Properties

XLogP1.9
Topological polar surface area48.9
Hydrogen bond donors2
Hydrogen bond acceptors2
Rotatable bonds0
Heavy atoms10
Formal charge0
Complexity129
Melting point217.0 to 221.0 °C
Boiling point366.5±15.0 °C(Predicted)
Density1.434±0.06 g/cm3(Predicted)
Storage conditionsInert atmosphere,Room Temperature
Solubilitysoluble in Methanol
Physical statepowder to crystal
pKa (acidity coefficient)9.17±0.40(Predicted)
ColorLight yellow to Yellow to Orange
InChIInChI=1S/C7H6N2O/c10-6-2-1-5-4-8-9-7(5)3-6/h1-4,10H,(H,8,9)
InChIKeyNUYZVDBIVNOTSC-UHFFFAOYSA-N
SMILESN1C2=C(C=CC(O)=C2)C=N1
CAS DataBase Reference23244-88-4
EWG's Food Scores1
UNSPSC Code12352100
NACRESNA.22
GHS pictogramGHS07
Signal wordWarning
GHS hazard statementsH302
GHS precautionary statementsP501-P270-P264-P301+P312+P330
Hazard symbolsXn
Risk statements (R)22
Water hazard class (WGK)3
RTECS numberNK8010000
Customs code2933998090
Storage class11 - Combustible Solids
Hazard classAcute Tox. 4 Oral
Toxicitymouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04549,

Safety & Regulations

GHS classificationWarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 44 reports by companies from 2 notifications to the ECHA C&L Inventory.
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Water hazard class (WGK)3
RTECS numberNK8010000
Customs code2933998090
Toxicitymouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04549,
Risk statements (R)22
Signal wordWarning
GHS pictogramGHS07
Hazard symbolsXn
Storage class11 - Combustible Solids
GHS hazard statementsH302
Hazard classAcute Tox. 4 Oral
GHS precautionary statementsP501-P270-P264-P301+P312+P330

Applications & Uses

Uses

6-Hydroxyinazole is a light brown powder and an important pharmaceutical intermediate used to construct the core of active drug molecules. It has broad application prospects in the synthesis and screening of small molecule chemical drugs. 6-Hydroxyinazole has neuroprotective effects. Indazole and its derivatives possess various biological activities, such as anti-inflammatory, antitumor, antioxidant, hypoglycemic, anti-HIV, anti-tuberculosis, antiplatelet, and 5-HT3 receptor antagonism. In addition, indazole derivatives are widely used in herbicides and dyes. Indazole was originally defined as a "pyrazole-ringed benzene ring," belonging to the azole family. It contains only three elements: carbon, hydrogen, and oxygen, and is an aromatic heterocycle containing 10 electrons. Theoretically, depending on whether there are hydrogen atoms on the two nitrogen atoms, indazole exists in two tautomeric forms: 1H-indazole and 2H-indazole. When there are no substituents on the indazole, it mainly exists in the 1H-indazole form.