Basic information
- CAS
25371-96-4- Standard SMILES
FC(F)(F)c1ccccc1-n1ccnc1- InChIKey
WZBWBNCQUTXYEL-UHFFFAOYSA-N- Molecular formula
- C10H7F3N2
- Average molar mass
- 212.17 g/mol
- Monoisotopic mass
- 212.05613272
Overview
1-[2-(trifluoromethyl)phenyl]imidazole is a member of imidazoles.
Names & identifiers
- Preferred name
- Trim
- IUPAC
- 1-[2-(trifluoromethyl)phenyl]imidazole
- English name
- 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
- Molecular formula
- C10H7F3N2
- Molecular weight
- 212.17
Names & synonyms
Trim25371-96-41-(2-Trifluoromethylphenyl)imidazole1-(2-(Trifluoromethyl)phenyl)-1H-imidazole1-[2-(Trifluoromethyl)phenyl]-1H-imidazoleDTXSID90452171-TRIMDTXCID7025217RefChem:74216636-734-91-[2-(trifluoromethyl)phenyl]imidazoleMFCD00041206
Show more names
TRIM, 10 mM in DMSOI-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE1-(2-Trifluoromethylphenyl)imidazole, 98+%1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]-1-[2-(Trifluoromethyl)phenyl]-1H-imidazole98%1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 98%2-chloro-3-(dodecylamino)naphthalene-1,4-dione
1-[2-(trifluoromethyl)phenyl] imidazoleCHEMBL277525NCGC00016047-03[2-(trifluoromethyl)phenyl]imidazoleCAS-25371-96-4SR-01000076173Tocris-0919Lopac-T-7313
Database identifiers
- CAS
25371-96-4- PubChem CID
Properties
Computed structural properties
- XLogP
- 2.6
- Topological polar surface area
- 17.8 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 1
- Heavy atoms
- 15
- Formal charge
- 0
- Complexity
- 217
Experimental & physicochemical properties
Solubility30.2 [ug/mL] (The mean of the results at pH 7.4)
Physicochemical properties
- Melting point
- 43 °C · 43 °C
- Boiling point
- 75 °C · 75°C 0,02mm
- Density
- 1.3253 · 1.3253 (estimate)
- Flash point
- 75 °C/0.025mm · 75°C/0.025mm
- storage temp.
- 2 · 2-8°C
- solubility
- Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).
- form
- White solid.
- pka
- 4.96 · 4.96±0.10(Predicted)
- color
- White
- biological source
- synthetic (organic)
- Sensitive
- Light Sensitive
- BRN
- 3955637 · 3955637
- Stability
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (93.9%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 49 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (93.9%)
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- hs_code
- 29339900
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- hazard_note
- Irritant
- safety_code
- 26-36
- hazard_class
- IRRITANT, LIGHT SENSITIVE
- Storage Class
- 11 - Combustible Solids
- target organs
- Respiratory system
- Hazard statements
- H315-H319-H335
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
Chemistry & industry
Applications
DescriptionTRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1TRIM displays antinociceptive activityin vivo.2
UsesTRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models.
Suppliers55 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
郑州汇聚化工有限公司13393710386 · [email protected]
上海仲因实业有限公司2537653158 16621191650 · [email protected]
Aladdin Scientific[email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
阿法埃莎（中国）化学有限公司400-6106006 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
天津希恩思生化科技有限公司400 638 7771 · [email protected]
Related reactions
1 records
Compound notes
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