Basic information
- CAS
1202867-00-2- Standard SMILES
O.O=C(N/N=C/c1ccc(O)c(O)c1)c1cc2ccccc2cc1O- InChIKey
FKWZHQSDBMSHTN-ZIOFAICLSA-N- Molecular formula
- C18H16N2O5
- Average molar mass
- 340.3 g/mol
- Monoisotopic mass
- 340.10592162
Names & identifiers
- Preferred name
- Dynasore hydrate
- IUPAC
- N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide;hydrate
- English name
- Dynasore hydrate
- Molecular formula
- C18H16N2O5
- Molecular weight
- 340.33004
Names & synonyms
Dynasore hydrate1202867-00-2N'-(3,4-Dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide hydrate(1:x)1217212-80-0N'-(3,4-Dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide hydrateSCHEMBL29435816DTXSID90746662EX-A269N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide;hydrate3-Hydroxy-N'-[(Z)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]naphthalene-2-carbohydrazide--water (1/1)
Database identifiers
- CAS
1202867-00-2- PubChem CID
- 136239889
- DTXSID
DTXSID90746662- EC Number
- 689-637-9
Properties
Computed structural properties
- Topological polar surface area
- 103 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 3
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 470
Physicochemical properties
- storage temp.
- -20 °C · -20°C
- solubility
- 10 mg/mL · DMSO: ≥10mg/mL
- form
- powder
- color
- off-white
- InChI
- 1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
- InChIKey
- FKWZHQSDBMSHTN-ZIOFAICLSA-N
- SMILES
- O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 9 · GHS09
- Signal word
- Warning
- Hazard statements
- 400 · H400
- Precautionary statements
- 273 · P273
- PPE
- Eyeshields, Gloves
- Hazard Codes
- N
- Risk Statements
- 50 · 50
- Safety Statements
- 22 · 22-24/25-61
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
P273, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAquatic Acute 1 (100%)
Safety data
- PPE
- Eyeshields, Gloves
- wgk
- 3
- ridadr
- UN 3077 9 / PGIII
- risk_code
- 50
- Signal word
- Warning
- Symbol(GHS)
- GHS09
- hazard_code
- N
- safety_code
- 22-24/25-61
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H400
- Hazard Classifications
- Aquatic Acute 1
- Precautionary statements
- P273
Chemistry & industry
Applications
UsesDynasore hydrate has been used:for priming fetal mesenchymal stem/stromal cells (fMSC)in confocal microscopyin wound healing/scratch and tube-formation assayto analyse its effects on Coxsackievirus A9 (CAV9) infectionto inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosisin live imaging of cells
General DescriptionDynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
Suppliers3 total
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
成都标样生物科技有限公司028-81700200 13308200041 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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