CAS 15448-47-2 (R)-1,2-Epoxypropane (HCID 146261)

Overview

(R)-1,2-epoxypropane is a 1,2-epoxypropane. It is an enantiomer of a (S)-1,2-epoxypropane.

Names & identifiers

Preferred name: (R)-1,2-Epoxypropane
IUPAC: (2R)-2-methyloxirane
English name: (R)-(+)-Propylene oxide
Molecular formula: C3H6O
Molecular weight: 58.08

Names & synonyms

(2R)-2-methyloxirane(R)-1,2-Epoxypropane(+)-Propylene oxideOxirane, methyl-, (2R)-Oxirane, methyl-, (R)-Propylene oxide, (R)-(+)-CHEBI:28985EC 604-958-6DTXSID201320388(R)-(+)-1,2-Propylene oxideRefChem:407088DTXCID801749805

Show more names

(R)-2-Methyloxirane(R)-(+)-PropyLR(+)-METHYLOXIRANE(r)-(+)-propyleneoxidChiral Propylene Oxide

Oxirane, methyl-, (R)-(9CI)604-958-6(R)-(+)-propylene oxide15448-47-2(R)-Propylene oxide(R)-Methyloxirane(R)-Epoxypropane(+)-Methyloxirane

Database identifiers

CAS: 15448-47-2
PubChem CID: 146261
DTXSID: DTXSID201320388
ChEMBL: CHEMBL1901974
ChEBI: CHEBI:28985
EC Number: 604-958-6
Nikkaji: J471.948D

Properties

Computed structural properties

XLogP: 0
Topological polar surface area: 12.5 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 1
Rotatable bonds: 0
Heavy atoms: 4
Formal charge: 0
Complexity: 26.5

Experimental & physicochemical properties

DrugsPharmaceuticals -> Listed in ZINC15

Physicochemical properties

Melting point: -111.91 °C · -111.91°C (estimate)
alpha: 14 · 14 º (neat)
Boiling point: 33 · 33-34 °C(lit.)
Density: 0.829 g/mL · 0.829 g/mL at 20 °C(lit.)
vapor pressure: 588 hPa · 588 hPa (20 °C)
refractive index: 20 · n20/D 1.366(lit.)
Flash point: -31 °F · -31 °F
storage temp.: 20 °C · Store at <= 20°C.
solubility: 405 g/l · 405g/l
form: clear liquid
color: Colorless to Almost colorless
optical activity: 20 · [α]20/D +14°, neat
explosive limit: 1.9 · 1.9-37%(V)
Water Solubility: Miscible with water and many organic solvents.
Merck: 14 · 14,7856
BRN: 79764 · 79764
InChI: 1S/C3H6O/c1-3-2-4-3/h3H,2H2,1H3/t3-/m1/s1
InChIKey: GOOHAUXETOMSMM-GSVOUGTGSA-N
SMILES: C[C@@H]1CO1
LogP: 0.03 · 0.03-0.085
CAS DataBase Reference: 15448 · 15448-47-2(CAS DataBase Reference)
UNSPSC Code: 12352005 · 12352005
NACRES: 22 · NA.22
Symbol(GHS): 2 · GHS02,GHS06,GHS08
Signal word: Danger
Hazard statements: 224 · H224-H302-H311+H331-H315-H319-H335-H340-H350
Precautionary statements: 210 · P210-P233-P280-P303+P361+P353-P308+P313-P403+P233
target organs: Respiratory system
PPE: Eyeshields, Faceshields, Gloves
Hazard Codes: F+,T
Risk Statements: 12 · 12-25-2017/12/25
Safety Statements: 45 · 45
RIDADR: 1280 · UN 1280 3/PG 1
WGK Germany: 3 · 3
RTECS: 2650000 · UJ2650000
Autoignition Temperature: 430 °C · 430 °C DIN 51794
HS Code: 2910 · 2910 20 00
HazardClass: 3 · 3
PackingGroup: I
Storage Class: 3 · 3 - Flammable liquids
Hazard Classifications: 3 DermalAcute · Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 4 OralCarc. 1BEye Irrit. 2Flam. Liq. 1Muta. 1BSkin Irrit. 2STOT SE 3
Toxicity: 50 orally · LD50 orally in Rabbit: 380 mg/kg LD50 dermal Rabbit 1243 mg/kg
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 6 items

Danger

H224 (100%): Extremely flammable liquid and vapor [Danger Flammable liquids]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 49 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]

Hazard information

Regulatory Information · 3 items

Chemical: Oxirane, methyl-, (R)-

Status: Active Update: 28-02-2011 https://echa.europa.eu/registration-dossier/-/registered-dossier/6315

(R)-(+)-1,2-Propylene oxide: HSNO Approval: HSR004105 Approved with controls

Other Safety InformationIMAP assessments - Methyloxirane (R-, S- and (R,S)-): Human health tier II assessment

Hazard Classes and Categories · 2 items

Flam. Liq. 1 (100%)

Acute toxicity - category 4

Safety data

PPE: Eyeshields, Faceshields, Gloves
wgk: 3
rtecs: UJ2650000
ridadr: UN 1280 3/PG 1
hs_code: 2910 20 00
Toxicity: LD50 orally in Rabbit: 380 mg/kg LD50 dermal Rabbit 1243 mg/kg
risk_code: 12-25-2017/12/25
Signal word: Danger
Symbol(GHS): GHS02,GHS06,GHS08
hazard_code: F+,T
safety_code: 45
hazard_class: 3
Storage Class: 3 - Flammable liquids
packing_group: I
target organs: Respiratory system
Hazard statements: H224-H302-H311+H331-H315-H319-H335-H340-H350
REACH Registrations: Active
Hazard Classifications: Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 4 OralCarc. 1BEye Irrit. 2Flam. Liq. 1Muta. 1BSkin Irrit. 2STOT SE 3
Autoignition Temperature: 430 °C DIN 51794
Precautionary statements: P210-P233-P280-P303+P361+P353-P308+P313-P403+P233

Chemistry & industry

Applications · 1 item

Uses(R)-(+)-Propylene oxide is widely utilized in the manufacture of polyether polyols and propylene glycol, which is used to make the polyurethane plastics. It finds application as a fumigant for the sterilization of packaged foods and plastic medical instruments. Combine with ethanol, it used to make biological samples for electron microscopy. It also used in model aircraft and surface vehicles as a glow fuel.