LY-127210 free base
Basic information
- CAS
57184-68-6- Standard SMILES
COc1cc2c(cc1OC)CC(N)=NC=C2- InChIKey
WADYQLCXAVXCQZ-UHFFFAOYSA-N- Molecular formula
- C12H14N2O2
- Average molar mass
- 218.25 g/mol
- Monoisotopic mass
- 218.10552769
Names & identifiers
- Preferred name
- LY-127210 free base
- IUPAC
- 7,8-dimethoxy-1H-3-benzazepin-2-amine
- English name
- 1H-3-Benzazepin-2-amine, 7,8-dimethoxy-
- Molecular formula
- C12H14N2O2
- Molecular weight
- 218.25
Names & synonyms
LY-127210 free base57184-68-67,8-dimethoxy-1H-3-benzazepin-2-amine1H-3-Benzazepin-2-amine, 7,8-dimethoxy-2-Amino-7,8-dimethoxy-1H-3-benzazepine7,8-Dimethoxy-1H-benzo[d]azepin-2-amine921U78MPPLLY127210UNII-921U78MPPLstarbld0007497LY127210 free baseLY127210 (free base)
Show more names
LY127210 free base,LY 127210 free base
orb1700051SCHEMBL11041640DTXSID40276404AKOS040748832DB-337248HY-129706T27930(7,8-dimethoxy-1H-[3]benzazepin-2-yl)-amine
Database identifiers
- CAS
57184-68-6- PubChem CID
- 146401
- DTXSID
DTXSID40276404- UNII
- 921U78MPPL
- Nikkaji
- J404.499A
Properties
Computed structural properties
- XLogP
- 0.9
- Topological polar surface area
- 56.8 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 16
- Formal charge
- 0
- Complexity
- 301
Physicochemical properties
- FDA UNII
- 921 U78MPPL · 921U78MPPL
Chemistry & industry
Applications
UsesLY127210 (free base) is a potent vasodilator with antihypertensive effects that reduces pressure in chloralose-anesthetized spontaneously hypertensive rats primarily by direct arteriolar dilation and to a lesser extent by decreasing cardiac output. LY127210 (free base) reduces blood pressure, heart rate and left ventricular end-diastolic pressure in hypertensive rats by reducing vascular resistance[1].
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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