Phenazocine
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Basic information
- CAS
127-35-5- Standard SMILES
CC1C2Cc3ccc(O)cc3C1(C)CCN2CCc1ccccc1- InChIKey
ZQHYKVKNPWDQSL-UHFFFAOYSA-N- Molecular formula
- C22H27NO
- Average molar mass
- 321.5 g/mol
- Monoisotopic mass
- 321.20926449
Overview
Phenazocine is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence. It is a Opiates substance.
Names & identifiers
- Preferred name
- Phenazocine
- IUPAC
- 1,13-dimethyl-10-(2-phenylethyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
- English name
- phenazocine
- Molecular formula
- C22H27NO
- Molecular weight
- 321.46
Names & synonyms
PHENAZOCINEPhenethylazocineFenazocinaPhenobenzorphanPhenazocinum127-35-52,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(2-phenylethyl)-IDS-NP-008DTXSID908607362'-Hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphanHydrobromide, PhenazocinePhenbenzorphan
Show more names
SKF-6574PrinadolZQHYKVKNPWDQSL-NKDCDXMNSA-N1,2,3,4,5,6-Hexahydro-6,11-diMethyl-3-phenethyl-2,6-Methano-3-benzazocin-8-ol1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-phenylethyl)-2,6-methano-3-benzazocin-8-ol
J0ND6N0AQCCHEBI:8056RefChem:172642DTXCID20197320N02AD021,13-dimethyl-10-(2-phenylethyl)-10-azatricyclo(7.3.1.02,7)trideca-2(7),3,5-trien-4-ol204-835-3NIH 7519
Database identifiers
- CAS
127-35-5、58073-76-0- PubChem CID
Properties
Computed structural propertiesFilling in
- XLogP
- 3.8
- Topological polar surface area
- 23.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 3
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 432
Experimental & physicochemical properties
Drugs
DEA NFLIS-Drug Category -> Narcotic Analgesics
DEA Schedule II Controlled Substance -> Opiates
Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds
Human DrugsPharmaceuticals
Endocrine DisruptorsPotential endocrine disrupting compound
Physicochemical properties
- Melting point
- 181 °C · 181 °C
- Boiling point
- 460.995 · 460.995±45.00 °C(Press: 760.00 Torr)(predicted)
- Density
- 1.097 · 1.097±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- pka
- 8.5 · pKa 8.50(50% aq EtOH) (Uncertain)
- FDA UNII
- 0 ND6N0AQC · J0ND6N0AQC
- ATC code
- 2 AD02 · N02AD02
- DEA Controlled Substances
- 9715 CSA · CSCN: 9715CSA SCH: Schedule IINARC: Yes
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Hazard information
Regulatory InformationDEA schedule II controlled substance
Safety data
- DEA Controlled Substances
- CSCN: 9715CSA SCH: Schedule IINARC: Yes
Chemistry & industry
Pharmacology
ATC Code
N - Nervous system
QN - Nervous system
MeSH Pharmacological Classification
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
Uses & manufacturing
Use ClassificationPharmaceuticals
Applications
UsesPhenazocine is an opioid analgesic drug related to Pentazocine (P274300) and has a similar profile of effects. The use of Phenazocine results in analgesia and euphoria and in some cases dysphoria and hallucinations at high doses, most likely due to action at κ-opioid and σ receptors. Phenazocine is a much more potent analgesic than morphine with about 4 times the potency and very little side effects making it a better treatment option for biliary or pancreatic pain. Controlled Substance.
Upstream & downstream products
Upstream raw materials
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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