Basic information
- CAS
129551-91-3- Standard SMILES
CCCC(=O)[O-].CCCC(=O)[O-].N.NC1CCCCC1.[Cl-].[Cl-].[Pt+4]- InChIKey
XMOWMXXEICQRQH-UHFFFAOYSA-J- Molecular formula
- C14H30Cl2N2O4Pt
- Average molar mass
- 556.4 g/mol
- Monoisotopic mass
- 555.123057
Overview
structure given in first source
Names & identifiers
- Preferred name
- JM 221
- IUPAC
- azane;butanoate;cyclohexanamine;platinum(4+);dichloride
- English name
- JM 221
- Molecular formula
- C8H14Cl2O4Pt.C6H13N.H3N
- Molecular weight
- 556.387
Names & synonyms
129551-91-3JM 221JM-221Platinum, amminebis(butanoato-O)dichloro(cyclohexanamine)-, (OC-6-43)-RefChem:150502Ammine dibutyratodichloro(cyclohexylamine)platinum IVazane;butanoate;cyclohexanamine;platinum(4+);dichlorideDTXSID80926431cis,trans,cis-Amine(cyclohexylamine)dibutyratodichloroplatium(IV)(OC-6-43)-Amminebis(butanoato-O)dichloro(cyclohexanamine)platinumPlatinum(4+) chloride butanoate--cyclohexanamine--ammonia (1/2/2/1/1)
Database identifiers
- CAS
129551-91-3- PubChem CID
- 148147
- DTXSID
DTXSID80926431
Properties
Computed structural properties
- Topological polar surface area
- 107 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 2
- Heavy atoms
- 23
- Formal charge
- 0
- Complexity
- 90.1
Chemistry & industry
Applications
DescriptionJM-221 is a novel platinum(IV) dicarboxylate complex exhibiting enhanced cytotoxicity in human ovarian carcinoma cell line when compared to Cisplatin. Comparison with platinum accumulation from Cisplatin suggests that the increased cytotoxicity of JM-221 may be related_x000D_ to increased accumulation within the cell. JM-221 is more lipophilic than Cisplatin, which may account for improved uptake in Cisplatin resistant cells.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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