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Basic information
- CAS
157716-52-4- Standard SMILES
CCCCCCCCCCCCCCCCCCOP(=O)(O)OC1CC[N+](C)(C)CC1- Molecular formula
- C25H52NO4P
- Average molar mass
- 461.663 g/mol
Names & identifiers
- Preferred name
- Perifosine (KRX-0401)
- English name
- Perifosine (KRX-0401)
- Molecular formula
- C25H52NO4P
- Molecular weight
- 461.663
Names & synonyms
PerifosineCS-449D21266D 21266D-21266KRX0401KRX 0401KRX-0401NSC 639966KRX-0401, NKA17
Database identifiers
- CAS
157716-52-4- PubChem CID
- 148178
- Nikkaji
- J2.669.413B
Properties
Physicochemical properties
- Melting point
- 271 · 271-272° (dec)
- storage temp.
- -20 °C · -20°C
- solubility
- 2 O: · H2O: soluble10mg/mL, clear
- form
- powder
- color
- white to beige
- Water Solubility
- 2 O: · H2O: 10mg/mL, clear
- InChI
- InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3
- InChIKey
- SZFPYBIJACMNJV-UHFFFAOYSA-N
- SMILES
- C1(OP([O-])(=O)OCCCCCCCCCCCCCCCCCC)CC[N+](C)(C)CC1
- CAS DataBase Reference
- 157716 · 157716-52-4
- NCI Dictionary of Cancer Terms
- perifosine
- FDA UNII
- 2 GWV496552 · 2GWV496552
- NCI Drug Dictionary
- perifosine
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 2 · GHS02
- Signal word
- Warning
- Hazard statements
- 226 · H226
- Precautionary statements
- 501 · P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235
- WGK Germany
- 3 · 3
- HS Code
- 2933399990 · 2933399990
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- hs_code
- 2933399990
- Signal word
- Warning
- Symbol(GHS)
- GHS02
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H226
- Precautionary statements
- P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235
Chemistry & industry
Applications
DescriptionPerifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.
UsesAntineoplastic.
UsesAn alkylphospholipid which inhibits Akt activation and the anti-apoptotic MAPK pathway.
UsesIt acts as an Akt inhibitor and a PI3K inhibitor, and is a drug candidate being developed for a variety of cancer indications.
Suppliers100 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
上海晶抗生物工程有限公司021-54721350 13524668266 · [email protected]
上海波以尔化工有限公司[email protected]
大连美仑生物技术有限公司0411-62910999 13889544652 · [email protected]
扬州思域化工有限公司0514-87325867 · [email protected]
China Kouting Group Limited+86 (21) 5811-6473 5811-6475 · [email protected]
Advanced chemblocks inc650-6922368 650-6922368;650-6922368 · [email protected]
成都普思生物科技股份有限公司
Related reactions
0 records
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Compound notes
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