Basic information
- CAS
154235-83-3- Standard SMILES
O=C(c1ccc2nccnc2c1)N1CCCCC1- InChIKey
ANDGGVOPIJEHOF-UHFFFAOYSA-N- Molecular formula
- C14H15N3O
- Average molar mass
- 241.29 g/mol
- Monoisotopic mass
- 241.1215121
Overview
CX-516 is a N-acylpiperidine.
Names & identifiers
- Preferred name
- 1-(Quinoxalin-6-ylcarbonyl)piperidine
- IUPAC
- piperidin-1-yl(quinoxalin-6-yl)methanone
- English name
- Ampalex
- Molecular formula
- C14H15N3O
- Molecular weight
- 241.29
Names & synonyms
Ampalex154235-83-3CX5161-(quinoxalin-6-ylcarbonyl)piperidine1-(6-Quinoxalinylcarbonyl)piperidineBDP-12CX 516Piperidine, 1-(6-quinoxalinylcarbonyl)-1-piperidyl(quinoxalin-6-yl)methanoneZ5QU38B4V9DTXSID701655746-((piperidin-1-yl)carbonyl)quinoxaline
Show more names
AMpakine CX516Ampalex, >=98%BDP-12(Ampalex)AMpalex (CX-516)CX516, 10 mM in DMSOAMPAKINE CX516SPD-420, BDP-12, CX-516, AMpalex
6-[(piperidin-1-yl)carbonyl]quinoxalineRefChem:580099DTXCID3088065piperidin-1-yl(quinoxalin-6-yl)methanoneCX-516BDP 12MFCD00943201173047-75-1
Database identifiers
- CAS
154235-83-3- PubChem CID
- 148184
- DTXSID
DTXSID70165574- ChEMBL
CHEMBL136800- ChEBI
Properties
Computed structural properties
- XLogP
- 1.8
- Topological polar surface area
- 46.1 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 301
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Melting point
- 88 · 88-90°C
- Boiling point
- 433.1 · 433.1±25.0 °C(Predicted)
- Density
- 1.236 · 1.236±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- Chloroform, Methanol
- pka
- -0.14 · -0.14±0.30(Predicted)
- form
- powder
- color
- white to light brown
- Water Solubility
- 2 O: · H2O: 5mg/mL, clear
- InChI
- 1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2
- InChIKey
- ANDGGVOPIJEHOF-UHFFFAOYSA-N
- SMILES
- O=C(C1=CC2=NC=CN=C2C=C1)N3CCCCC3
- EWG's Food Scores
- 1 · 1
Safety & regulation
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- WGK 3
- rtecs
- TM2785170
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302
- Hazard Classifications
- Acute Tox. 4 Oral
- Precautionary statements
- P264-P270-P301+P312-P330-P501
Chemistry & industry
Pharmacology
Mechanism of Action
CX 516 is a benzylpiperidine AMPAkine, an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) modulator, that enhances the function of glutamate when it binds allosterically to the AMPA receptor channel complex. CX 516 slows receptor deactivation with a longer open time, slower excitatory postsynaptic potential (EPSP) decay and improvement of hippocampal long term potentiation (LTP).
Applications
UsesAmpalex is a AMPA modulator that may exhibit therapeutic properties for treating Alzheimer''s disease, schizophrenia, and mild cognitive impairment (MCI) (1,2,3,4).
UsesIt is one of a series of AMPA modulators
Suppliers100 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
北京华威锐科化工有限公司0757-86329057 18934348241 · [email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
上海波以尔化工有限公司[email protected]
宁波亿诺化学品有限公司86-574-27787657 · [email protected]
北京亿思研科技开发中心010-56645598 13366904824 · [email protected]
上海恩诺生物科技有限公司+86 (21) 6435-5022
Related reactions
6 records
Compound notes
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