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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 1491Generated: October 23, 2026

2,4-Dihydroxybenzoic Acid

2,4-Dhba · 2,4-Dihydrox · BETA-RESORCYLIC ACID · 2,4-Dihydroxybenzoesure · 4-Dihydroxybenzoic acid · Sodium aminosalicylate Impurity 3 · 2,4-Dihydroxybenzoic Acid, ≥ 98.0% · 2,4-DIHYDROXYBENZOIC ACID / BETA-RESORCYLIC ACID

https://huagongshe.com/en/chemical/1491

2,4-Dihydroxybenzoic Acid molecular structure

Identifiers & Physical Properties

CAS No.89-86-1
Molecular formulaC7H6O4
Average molar mass154.12 g/mol
Monoisotopic mass154.02660867 g/mol
SMILESO=C(O)c1ccc(O)cc1O
InChIKeyUIAFKZKHHVMJGS-UHFFFAOYSA-N
PubChem CID1491
ChEMBLCHEMBL328910
ChEBICHEBI:42094
EC No.201-946-9
DTXSIDDTXSID0025074

Chemical & Physical Properties

XLogP1.6
Topological polar surface area77.8
Hydrogen bond donors3
Hydrogen bond acceptors4
Rotatable bonds1
Heavy atoms11
Formal charge0
Complexity157
LogP (partition coefficient)1.63
Solubility57805.78 mg/mL at 25 °Csoluble in hot water, organic solvents, oilssoluble (in ethanol)8g/l8 g/L (20 ºC)
Boiling point309.00 to 310.00 °C. @ 760.00 mm Hg237.46°C (rough estimate)
Melting point226218 - 219 °C208-211 °C (dec.) (lit.)
Vapor pressure0.0000021 [mmHg]0Pa at 25℃
Physical DescriptionSolid[Merck Index] White powder[Alfa Aesar MSDS]hydrated white crystals with a faint phenolic odour
Dissociation Constants3.11 (at 25 °C)
Kovats Retention Index1532
Density1.3725 (rough estimate)
Refractive index1.6710 (estimate)
FEMA3798 | 2,4-DIHYDROXYBENZOIC ACID
FLAVIS Number08.076 | 2,4-Dihydroxybenzoic acid
Flash point200 °C
Storage conditionsInert atmosphere,Room Temperature
Physical stateCrystalline Powder
pKa (acidity coefficient)3.11, 8.55, 14.0(at 25℃)
ColorCream to slightly beige or pink
Odorat 100.00%. mild phenolic
Biological sourcesynthetic
Merck14,8157
JECFA Number908
BRN1946213
Cosmetics Ingredients FunctionsSKIN CONDITIONING - EMOLLIENTSKIN CONDITIONING - MISCELLANEOUS
InChI1S/C7H6O4/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,8-9H,(H,10,11)
InChIKeyUIAFKZKHHVMJGS-UHFFFAOYSA-N
SMILESOC(=O)c1ccc(O)cc1O
LogP (partition coefficient)0.98 at 23℃ and pH3.5
Substances Added to Food (formerly EAFUS)2,4-DIHYDROXYBENZOIC ACID
CAS DataBase Reference89-86-1(CAS DataBase Reference)
EWG's Food Scores1
FDA UNIILU39SC9JYL
NIST Chemistry Reference2,4-Dihydroxybenzoic acid(89-86-1)
EPA Substance Registry System2,4-Resorcylic acid (89-86-1)
UNSPSC Code12352100
NACRESNA.22
GHS pictogramGHS07
Signal wordWarning
GHS hazard statementsH315-H319-H335
GHS precautionary statementsP261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Personal protective equipment (PPE)dust mask type N95 (US), Eyeshields, Gloves
Hazard symbolsXi
Risk statements (R)36/37/38
Safety statements (S)26-36-37/39
Water hazard class (WGK)1
RTECS numberVH3708050
TSCA inventory statusTSCA listed
Customs code29182990
Storage class11 - Combustible Solids
Hazard classSkin Sens. 1
REACH registrationsActive

Safety & Regulations

GHS classificationWarningH315 (89.1%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (90.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (87.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 55 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Regulatory informationChemical: Benzoic acid, 2,4-dihydroxy-Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Status: Active Update: 03-05-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/26724Status: Active Update: 16-10-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/20707Benzoic acid, 2,4-dihydroxy-: Does not have an individual approval but may be used under an appropriate group standard
Hazards summaryIntraperitoneal LD50 (mouse) > 800 mg/kg[RTECS] Safe when used as a flavoring agent in food[JECFA] A skin and strong eye irritant[Alfa Aesar MSDS]
Hazard Classes and CategoriesSkin Irrit. 2 (89.1%)Eye Irrit. 2A (90.9%)STOT SE 3 (87.3%)
Protective Action Criteria (PAC)10 [mg/m3]110 [mg/m3]660 [mg/m3]
Personal protective equipment (PPE)dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK)1
TSCA inventory statusTSCA listed
RTECS numberVH3708050
Customs code29182990
Risk statements (R)36/37/38
Signal wordWarning
GHS pictogramGHS07
Hazard symbolsXi
Safety statements (S)26-36-37/39
Storage class11 - Combustible Solids
GHS hazard statementsH315-H319-H335
REACH registrationsActive
Hazard classSkin Sens. 1
GHS precautionary statementsP261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Applications & Uses

Uses

2,4-Dihydroxybenzoic acid is a useful synthetic intermediate. An organic building block for plastics and rubber products.

Occurrence

Reported present in avocados, beer, red wine, roast coffee, sherry, smoked sausage and white wine

Uses

2,4-Dihydroxybenzoic acid is used in Intermediates, Plasticizers, Plastic and Rubber Products, a organic building block.

Uses

Intermediate for dyestuffs and drugs; spot test reagent for iron.

Preparation & Synthesis

Preparation

It is derived from the hydroxylation of resorcinol.

Preparation

Prepared from resorcinol and potassium bicarbonate in glycerol or water by heating and passing carbon dioxide through the mixture.