Basic information
- CAS
796-66-7- Standard SMILES
O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O)cc1F- InChIKey
RNBMPPYRHNWTMA-UAKXSSHOSA-N- Molecular formula
- C9H12FN2O9P
- Average molar mass
- 342.17 g/mol
- Monoisotopic mass
- 342.02644512
Overview
5-fluorouridine 5'-monophosphate is a pyrimidine ribonucleoside 5'-monophosphate having 5-fluorouracil as the pyrimidine component. It has a role as a drug metabolite. It is an organofluorine compound and a pyrimidine ribonucleoside 5'-monophosphate. It is functionally related to a uridine 5'-monophosphate.
Names & identifiers
- Preferred name
- 5-Fluorouridine 5'-monophosphate
- IUPAC
- [(2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
- English name
- 5-fluorouridine 5'-phosphate
- Molecular formula
- C9H12FN2O9P
- Molecular weight
- 342.17
Names & synonyms
796-66-75-Fluorouridine monophosphateFosfluoridine5-fluorouridine 5'-monophosphate5'-Uridylic acid, 5-fluoro-5-F-UMPCHEBI:40101RefChem:10729385-Fluorouridine 5'-phosphate5-Fluorouridylic acidFump-5'BMW6RNK254
Show more names
5-Fluorouridine-monophosphate Free acid5-Fluorouridine-5'-monophosphate, disodium salt5-Fluorouridine-5'-monophosphate sodium salt - 10mM aqueous solution
((2R,3S,4R,5R)-5-(5-Fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate5-Fluoro-Uridine-5'-Monophosphate5-fluorouridine 5'-(dihydrogen phosphate)5-Fluorouridylate[(2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate5-fluoro-UMPUNII-BMW6RNK254uridine derivative, 39
Database identifiers
- CAS
796-66-7- PubChem CID
- 150856
- DTXSID
DTXSID601000617- ChEMBL
Properties
Computed structural properties
- XLogP
- -3.6
- Topological polar surface area
- 166 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 4
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 563
Physicochemical properties
- Density
- 1.93 · 1.93±0.1 g/cm3(Predicted)
- pka
- 1.86 · 1.86±0.10(Predicted)
- FDA UNII
- 6 RNK254 · BMW6RNK254
Chemistry & industry
Pharmacology
Tissue LocationsKidney
Applications
Uses5-Fluorouridine 5'-phosphate is an ODCase (orotidine-5′-monophosphate decarboxylase) inhibitor, with a Ki value of 98 μM for human ODCase and a Ki value of 645 μM for Methanobacterium ODCase. 5-Fluorouridine 5'-phosphate exhibits inhibitory activity against leukemia and lymphoma cell lines and can be used in cancer research [1].
Suppliers12 total
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
济南德迈医药科技有限公司18669728830 15806766175 · [email protected]
上海梅凯科技有限公司021-68689288 15300790979 · [email protected]
安徽仕通生物科技有限公司15555170917 · [email protected]
上海皓鸿生物医药科技有限公司400-8210725 4008210725 · [email protected]
杭州六可生物科技有限公司+86-571-86912261 19975279805 · [email protected]
BOC Sciences16314854226 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
Related reactions
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Compound notes
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