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Basic information
- CAS
20584-81-0- Standard SMILES
N[C@@H](CCCNC(=O)CCl)C(=O)O- InChIKey
YOHUBSGWLQBGKD-YFKPBYRVSA-N- Molecular formula
- C7H13ClN2O3
- Average molar mass
- 208.645 g/mol
- Monoisotopic mass
- 208.06146996
Names & identifiers
- Preferred name
- N~5~-(2-Chloro-1-hydroxyethylidene)ornithine
- IUPAC
- N~5~-(2-Chloro-1-hydroxyethylidene)-L-ornithine
- English name
- N-delta-chloroacetyl-L-ornithine
- Molecular formula
- C7H13ClN2O3
- Molecular weight
- 208.64
Names & synonyms
NCAON-delta-chloroacetyl-L-ornithineL-Ornithine, N5-(2-chloroacetyl)-
Database identifiers
- CAS
20584-81-0- PubChem CID
- 152308
- DTXSID
DTXSID20942776- ChEMBL
CHEMBL2261746- Nikkaji
- J389.554H
Properties
Physicochemical properties
- Boiling point
- 469 · 469.0±45.0 °C(Predicted)
- Density
- 1.303 · 1.303±0.06 g/cm3(Predicted)
- pka
- 2.49 · 2.49±0.24(Predicted)
- form
- Solid
- color
- White to off-white
Chemistry & industry
Applications
UsesN-ω-chloroacetyl-L-ornithine (NCAO) is a potent reversible competitive ornithine decarboxylase (ODC) inhibitor that exerts cytotoxic and antiproliferative effects on tumor cell lines with EC50 values ranging from 1 to 50.6 μM. NCAO induces tumor cell Apoptosis and inhibits tumor cell migration in vitro. NCAO also exhibits a potent antitumor activity against both solid and ascitic tumors in a mouse model using the myeloma (Ag8) cell line. NCAO is promising for research of antitumor agents[1].
Suppliers1 total
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
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Compound notes
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