Basic information
- Standard SMILES
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cc3ccccc3cc2c1- InChIKey
ZITQUAHPZJHCJH-UHFFFAOYSA-N- Molecular formula
- C29H29Cl2N3O
- Average molar mass
- 506.5 g/mol
Overview
a dopamine D3 receptor antagonist; structure in first source
Names & identifiers
- Preferred name
- Ngb-2849
- IUPAC
- N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]anthracene-2-carboxamide
Names & synonyms
NGB284926P8N956NZNGB-2849197242-80-1RefChem:927696NGB 2849UNII-26P8N956NZN-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyl)-2-anthracenecarboxamide2-Anthracenecarboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)-N-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl}-2-anthracenecarboxamideorb1739455SCHEMBL8183795
Show more names
ZITQUAHPZJHCJH-UHFFFAOYSA-N
Database identifiers
- CAS
197242-80-1- PubChem CID
- 15411150
- UNII
- 26P8N956NZ
- Nikkaji
- J959.637B
Properties
Computed structural properties
- XLogP
- 7
- Topological polar surface area
- 35.6 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 7
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 685
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Related reactions
4 records
Linked notes
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