Basic information
- CAS
341-88-8- Standard SMILES
CCCCCCCc1cc(=O)c2ccccc2n1O- InChIKey
ICTVCUOZYWNYHM-UHFFFAOYSA-N- Molecular formula
- C16H21NO2
- Average molar mass
- 259.34 g/mol
- Monoisotopic mass
- 259.15722891
Overview
2-heptyl-4-hydroxyquinoline N-oxide is an inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559. It is a quinoline N-oxide and a monohydroxyquinoline.
Names & identifiers
- Preferred name
- 2-heptyl-4-hydroxyquinoline N-oxide
- IUPAC
- 2-heptyl-1-hydroxyquinolin-4-one
- English name
- 2-Heptyl-4-hydroxyquinoline N-oxide
- Molecular formula
- C16H21NO2
- Molecular weight
- 259.34
Names & synonyms
341-88-82-heptyl-4-hydroxyquinoline n-oxideHOQNO2-Heptyl-4-quinolinol 1-oxide2-heptylquinolin-4-ol 1-oxide2-(n-Heptyl)-4-hydroxyquinoline N-oxide2-Heptyl-4-hydroxyquinoline-N-oxide2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE1FU5S5CG6ACHEBI:28362HOQNO cpdKF-8940
Show more names
kf8940C04284Pyo IIAntibiotic KF-8940HQNO, 10 mM in DMSONZPACTGCRWDXCJ-UHFFFAOYSA-N2-heptyl-4-quinolino1-oxide
HHXQN-NORefChem:4728392-HQNO4-quinolinol, 2-heptyl, 1-oxide4-hydroxy-2-heptylquinoline-N-oxideHQNO2-Heptyl-4-hydroxyquinolin-1-ium-1-olate2-heptyl-1-hydroxyquinolin-4-one
Database identifiers
- CAS
341-88-8- PubChem CID
- 1561
- DTXSID
DTXSID20955644- ChEMBL
CHEMBL1233401
Properties
Computed structural properties
- XLogP
- 4.5
- Topological polar surface area
- 40.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 6
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 338
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Melting point
- 156 · 156-157°
- Boiling point
- 445.8 · 445.8±37.0 °C(Predicted)
- Density
- 1.09 · 1.09±0.1 g/cm3(Predicted)
- storage temp.
- 2 · Sealed in dry,2-8°C
- solubility
- Soluble in DMSO (up to 8 mg/ml with warming), or in Ethanol (up to 13 mg/ml with warming).
- pka
- 1.07 · 1.07±0.40(Predicted)
- form
- White to off-white crystalline solid.
- color
- White
- Stability
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- FDA UNII
- 1 FU5S5CG6A · 1FU5S5CG6A
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- rtecs
- VC5890000
- Toxicity
- LD50 intraperitoneal in mouse: 40mg/kg
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H312-H315-H319
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
DescriptionHQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR).
UsesHQNO is a streptomycin antagonist. A naturally occurring antagonist of dihydrostreptomycin.
Suppliers42 total
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
南京世洲生物科技有限公司025-025-85560043 17301488900 · [email protected]
Aladdin Scientific[email protected]
Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
InvivoChem中国13549236410 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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