Basic information
- CAS
1808-12-4- Standard SMILES
C[NH+](C)CCOC(c1ccccc1)c1ccc(Br)cc1.[Cl-]- InChIKey
ZQDJSWUEGOYDGT-UHFFFAOYSA-N- Molecular formula
- C17H21BrClNO
- Average molar mass
- 370.7 g/mol
- Monoisotopic mass
- 369.0495
Overview
Bromazine hydrochloride is the hydrochloride salt of bromazine. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies. It has a role as an antimicrobial agent, a H1-receptor antagonist, a histamine antagonist and a muscarinic antagonist. It is a hydrochloride and an organobromine compound.
Names & identifiers
- Preferred name
- bromazine HCl
- IUPAC
- 2-[(4-bromophenyl)-phenylmethoxy]ethyl-dimethylazanium chloride
- English name
- Bromazine Hydrochloride
- Molecular formula
- C17H21BrClNO
- Molecular weight
- 370.71174
Names & synonyms
bromazine HCl2-[(4-bromophenyl)-phenylmethoxy]ethyl-dimethylazanium;chlorideBromanyl (TN)orb1305367Diphenhydramine Impurity C hydrochlorideNS00082892D03166T251802-(p-bromo-alpha-phenylbenzyloxy)-N,N-dimethylethylamine hydrochloride2-[(4-bromophenyl)(phenyl)methoxy]-N,N-dimethylethanaminium chloride2-[(4-bromophenyl)(phenyl)methoxy]-N,N-dimethylethanamine hydrochloride (1:1)deserol
Show more names
bromazinCetirizine-dbromo-benzdrylEINECS 204-238-8ambodrylhydrochloridebromazine hydrochlorideBromodiphenhydramine HClDIPHENHYDRAMINE EP IMP C
Database identifiers
- CAS
1808-12-4
Properties
Computed structural properties
- Topological polar surface area
- 13.7 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 6
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 258
Physicochemical properties
- Melting point
- 144 · 144-145°
- storage temp.
- Refrigerator
- solubility
- Acetone (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- Pale Yellow
- BRN
- 3754363 · 3754363
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H
- InChIKey
- ZQDJSWUEGOYDGT-UHFFFAOYSA-N
- SMILES
- C(OCCN(C)C)(C1=CC=CC=C1)C1=CC=C(Br)C=C1.Cl
- FDA UNII
- 202 J683U97 · 202J683U97
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 24 · NA.24
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302
- Precautionary statements
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- WGK 1
- hs_code
- 2922190900
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302
- Hazard Classifications
- Acute Tox. 4 Oral
- Precautionary statements
- P301+P312+P330
Chemistry & industry
Applications
DescriptionBromodiphenhydramine is a histamine H1 receptor antagonist. It induces histamine release in isolated guinea pig lung when used at a concentration of 1 mM but completely prevents ovalbumin-induced histamine release in lungs isolated from ovalbumin-sensitized guinea pigs when used at concentrations of 100 and 200 μg/ml. Bromodiphenhydramine (17 mg/kg) inhibits formalin-induced paw edema in rats. It increases survival in a mouse model of systemic S. typhimurium infection when administered at doses of 1.5 and 3 mg/kg.
UsesAntihistaminic.
General DescriptionBromodiphenhydraminehydrochloride, 2-[(4-bromophenyl)-phenylmethoxy]-N, N-dimethylethanamine hydrochloride(Ambodryl Hydrochloride), is a white to pale buff crystallinepowder that is freely soluble in water and in alcohol.Relative to diphenhydramine, bromodiphenhydramine ismore lipid soluble and was twice as effective in protectingagainst the lethal effects of histamine aerosols.
Suppliers67 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
怀化元研达生物技术有限责任公司18711085600 · [email protected]
山东艾莎科技有限公司15092135101 · [email protected]
Related reactions
0 records
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Compound notes
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