Basic information
- CAS
1824-81-3- Standard SMILES
Cc1cccc(N)n1- InChIKey
QUXLCYFNVNNRBE-UHFFFAOYSA-N- Molecular formula
- C6H8N2
- Average molar mass
- 108.14 g/mol
- Monoisotopic mass
- 108.06874826
Names & identifiers
- Preferred name
- 2-Amino-6-methylpyridine
- IUPAC
- 6-methylpyridin-2-amine
- English name
- 2-Amino-6-methylpyridine
- Molecular formula
- C6H8N2
- Molecular weight
- 108.14
Names & synonyms
2-Amino-6-methylpyridine6-methylpyridin-2-amine2-Amino-6-picoline2-Pyridinamine, 6-methyl-6-Methyl-2-pyridinamine6-Methyl-2-pyridylamine2-Picoline, 6-amino-6-Amino-2-methylpyridine6-Methyl-2-aminopyridinePYRIDINE, 2-AMINO-6-METHYL-NSC 6971NSC 1488
Show more names
6-AMINO-2-PICOLINE2A6PCAKOS 91157AKOS BBS-00004344TIMTEC-BB SBB0043552-Amino-6-methylpyri6-methyl-2-pyridinamin
DTXSID0044860UNII-35ANN6MRBM35ANN6MRBM2-amino-6-methyl pyridineEINECS 217-360-1BRN 0107048AI3-24112NSC-1488
Database identifiers
- CAS
1824-81-3- PubChem CID
- 15765
- DTXSID
DTXSID0044860- ChEMBL
CHEMBL61591- UNII
- 35ANN6MRBM
- EC Number
- 217-360-1
- Nikkaji
- J38.381C
Properties
Computed structural properties
- XLogP
- 0.4
- Topological polar surface area
- 38.9 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 72
Experimental & physicochemical properties
Kovats Retention Index
1074
1893
Collision Cross Section119.5 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0044860]；118.6 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID0044860]
Physicochemical properties
- Melting point
- 40 · 40-44 °C(lit.)
- Boiling point
- 208 · 208-209 °C(lit.)
- Density
- 1.0275 · 1.0275 (estimate)
- refractive index
- 1.556 · 1.5560 (estimate)
- Flash point
- 218 °F · 218 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1 · pK1: 7.41(+1) (25°C)
- form
- Crystalline Low Melting Solid
- color
- Yellow
- Water Solubility
- very faint turbidity
- Sensitive
- Hygroscopic
- BRN
- 107048 · 107048
- InChI
- 1S/C6H8N2/c1-5-3-2-4-6(7)8-5/h2-4H,1H3,(H2,7,8)
- InChIKey
- QUXLCYFNVNNRBE-UHFFFAOYSA-N
- SMILES
- Cc1cccc(N)n1
- CAS DataBase Reference
- 1824 · 1824-81-3(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 35 ANN6MRBM · 35ANN6MRBM
- NIST Chemistry Reference
- 2 · 2-Pyridinamine, 6-methyl-(1824-81-3)
- EPA Substance Registry System
- 2 · 2-Pyridinamine, 6-methyl- (1824-81-3)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 6 · GHS06
- Signal word
- Danger
- Hazard statements
- 301 · H301-H310-H315-H319-H335
- Precautionary statements
- 262 · P262-P280-P301+P310+P330-P302+P352+P310-P305+P351+P338
- target organs
- Respiratory system
- PPE
- 2 · Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
- Hazard Codes
- T
- Risk Statements
- 25 · 25-36/37/38-24/25-23/24/25-24
- Safety Statements
- 26 · 26-36/37/39-45-37/39-28A
- RIDADR
- 2811 · UN 2811 6.1/PG 3
- WGK Germany
- 3 · 3
- RTECS
- 1885000 · US1885000
- F
- 10 · 10-21
- TSCA
- TSCA listed
- HazardClass
- 6.1 · 6.1
- PackingGroup
- II
- HS Code
- 29333999 · 29333999
- Storage Class
- 6.1 A · 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- Hazard Classifications
- 2 DermalAcute · Acute Tox. 2 DermalAcute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
Safety & regulation
GHS classification
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]；H310 (94.8%): Fatal in contact with skin [Danger Acute toxicity, dermal]；H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (98.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 58 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Regulatory Information
Chemical: 2-Pyridinamine, 6-methyl-
2-Amino-6-methylpyridine: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesAcute Tox. 3 (100%)；Acute Tox. 2 (94.8%)；Skin Irrit. 2 (100%)；Eye Irrit. 2A (100%)；STOT SE 3 (98.3%)
Regulatory information
Regulatory Information
Chemical: 2-Pyridinamine, 6-methyl-
2-Amino-6-methylpyridine: Does not have an individual approval but may be used under an appropriate group standard
Safety data
- F
- 10-21
- PPE
- Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- US1885000
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 29333999
- risk_code
- 25-36/37/38-24/25-23/24/25-24
- Signal word
- Danger
- Symbol(GHS)
- GHS06
- hazard_code
- T
- safety_code
- 26-36/37/39-45-37/39-28A
- hazard_class
- 6.1
- Storage Class
- 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- packing_group
- II
- target organs
- Respiratory system
- Hazard statements
- H301-H310-H315-H319-H335
- Hazard Classifications
- Acute Tox. 2 DermalAcute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
- Precautionary statements
- P262-P280-P301+P310+P330-P302+P352+P310-P305+P351+P338
Chemistry & industry
Uses & manufacturing
General Manufacturing Information2-Pyridinamine, 6-methyl-: ACTIVE
Applications
UsesIntermediate.
Uses2-Amino-6-methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Ka).
Description2-amino-6-methylpyridine, a colorless organic crystalline solid, is a prominent candidate to be exploited for the manufacturing of valuable compounds with biological activity.
Upstream & downstream products
Upstream raw materials
Downstream products
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Related reactions
193 records
Compound notes
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