A 65281
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Basic information
- CAS
111279-49-3- Standard SMILES
O=c1[nH]sc2c1c(=O)c1cc(F)c(N3CCNCC3)c(F)c1n2C1CC1- InChIKey
DMWIKVPTLPZXQB-UHFFFAOYSA-N- Molecular formula
- C17H16F2N4O2S
- Average molar mass
- 378.404 g/mol
- Monoisotopic mass
- 378.09620319
Names & identifiers
- Preferred name
- A 65281
- IUPAC
- 9-Cyclopropyl-6,8-difluoro-7-(piperazin-1-yl)[1,2]thiazolo[5,4-b]quinoline-3,4(2H,9H)-dione
- English name
- A 65281
- Molecular weight
- 0
Names & synonyms
A 652819-Cyclopropyl-6,8-difluoro-7-(1-piperazinyl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione
Database identifiers
- CAS
111279-49-3- PubChem CID
- 159353
- DTXSID
DTXSID30149577- Nikkaji
- J340.034D
Chemistry & industry
Applications
DescriptionA 65281 is an antibacterial isothiazoloquinolone. It induces considerable DNA breakage mediated by calf thymus topoisomerase II. A 65281 is a potent inhibitor of the P4-unknotting reaction.
UsesA 65281 is a potent DNA gyrase inhibitor with an IC50 value of 0.1 μg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II. A 65281 inhibits P4 DNA unknotting with an IC50 value of 8 μg/mL[1].
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Compound notes
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