Antiflammin P2
Basic information
- CAS
118850-72-9- Standard SMILES
CSCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)OC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C- InChIKey
MSFJEXCKZQTGKA-KSALCKNPSA-N- Molecular formula
- C46H77N13O15S
- Average molar mass
- 1,084.2 g/mol
- Monoisotopic mass
- 1,083.53827997
Overview
nonapeptide fragment of lipocortin I; has no phospholipase A2 inhibitory & anti-inflammatory activity; RN given refers to all (L)-isomer
Names & identifiers
- Preferred name
- Antiflammin P2
- IUPAC
- (3S)-4-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]oxy-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-4-oxobutanoic acid
- English name
- ANTI-INFLAMMATORY PEPTIDE 2
- Molecular formula
- C46H77N13O15S
- Molecular weight
- 1084.25
Names & synonyms
HdmnkvldlAntiflamin 2Histidyl-aspartyl-methionyl-asparaginyl-lysyl-valyl-leucyl-aspartyl-leucineHIS-ASP-MET-ASN-LYS-VAL-LEU-ASP-LEURefChem:113139118850-72-9Antiflammin P2SCHEMBL29391972(3S)-4-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]oxy-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-4-oxobutanoic acidL-Leucine, N-(N-(N-(N-(N2-(N2-(N-(N-L-histidyl-L-alpha-aspartyl)-L-methionyl)-L-asparaginyl)-L-lysyl)-L-valyl)-L-leucyl)-L-alpha-aspartyl)-PEPTIDE 2ANTIFLAMMIN-2
Show more names
ANTIFLAMMIN P 2ANTI-INFLAMMATORY PEPTIDE 2H-HIS-ASP-MET-ASN-LYS-VAL-LEU-ASP-LEU-OHAnti-InflaMMatory Peptide 2 AntiflaMMin-2
Properties
Computed structural properties
- XLogP
- -6.9
- Topological polar surface area
- 497 Ų
- Hydrogen bond donors
- 14
- Hydrogen bond acceptors
- 20
- Rotatable bonds
- 38
- Heavy atoms
- 75
- Formal charge
- 0
- Complexity
- 1,980
Physicochemical properties
- storage temp.
- 20 °C · −20°C
- form
- Lyophilized powder
- color
- White to off-white
- WGK Germany
- 3 · 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Applications
UsesAntiflammin 2 inhibits the synthesis of platelet-activating factor (PAF) with the IC50 of 100 nM[1].
Related reactions
0 records
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Compound notes
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