Acth (6-9)
Basic information
- CAS
4289-02-5- Standard SMILES
NC(N)=NCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(C(=O)[C@@H](N)Cc2cnc[nH]2)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O- InChIKey
ZFIWNOVWFLTRKY-DROSFRCNSA-N- Molecular formula
- C32H40N10O5
- Average molar mass
- 644.7 g/mol
- Monoisotopic mass
- 644.31831441
Overview
tetrapeptide which is the biologically active amino acid sequence of alpha-MSH
Names & identifiers
- Preferred name
- Acth (6-9)
- IUPAC
- (2S)-2-[[(2S)-2-[[(2S)-2-amino-3-[4-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]phenyl]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
- English name
- ACTH (6-9)
- Molecular formula
- C32H40N10O5
- Molecular weight
- 644.73
Names & synonyms
Histidyl-phenylalanyl-arginyl-tryptophanActh (6-9)His-phe-arg-trp-DTXSID90195550RefChem:109481DTXCID301180414289-02-5(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-[4-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]phenyl]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidL-Tryptophan, N-(N2-(N-L-histidyl-L-phenylalanyl)-L-arginyl)-4-[(2S)-2-Amino-3-(1H-imidazol-5-yl)propanoyl]-L-phenylalanyl-N~5~-(diaminomethylidene)-L-ornithyl-L-tryptophanHisetalα-MSH(6-9)
Show more names
γ2-MSH(5-8)α-Melanotropin(6-9)【pig】α1-24-Corticotropin(6-9)L-Tryptophan, L-histidyl-L-phenylalanyl-L-arginyl-Characteristic MSH-Tetrapeptide H-His-Phe-Arg-Trp-OH(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-[4-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]phenyl]propanoyl]amino]-5-guanidino-pentanoyl]amino]-3-(1H-indol-3-yl)propionic acid
Properties
Computed structural properties
- XLogP
- -3.3
- Topological polar surface area
- 273 Ų
- Hydrogen bond donors
- 9
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 17
- Heavy atoms
- 47
- Formal charge
- 0
- Complexity
- 1,100
Physicochemical properties
- Density
- 1.45 · 1.45±0.1 g/cm3(Predicted)
- pka
- 3.36 · 3.36±0.10(Predicted)
- Sequence
- His-Phe-Arg-Trp
Chemistry & industry
Applications
UsesACTH (6-9) (MSH-ACTH tetrapeptide) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1].
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Compound notes
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