T-cadinol
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Basic information
- CAS
5937-11-1- Standard SMILES
CC1=C[C@@H]2[C@@H](CC1)[C@@](C)(O)CC[C@H]2C(C)C- InChIKey
LHYHMMRYTDARSZ-XQLPTFJDSA-N- Molecular formula
- C15H26O
- Average molar mass
- 222.37 g/mol
Names & identifiers
- Preferred name
- T-cadinol
- English name
- T-cadinol
- Molecular formula
- C15H26O
- Molecular weight
- 222.37
Names & synonyms
T-cadinolCedrelanol10-Epicadinolepi-α-cadinol10-epi-α-Cadinol(1S)-1,2,3,4,4aβ,7,8,8aα-Octahydro-1,6-dimethyl-4β-isopropyl-1-naphthol(1S)-1,2,3,4,4aβ,7,8,8aα-Octahydro-1,6-dimethyl-4β-isopropylnaphthalen-1β-ol1-Naphthalenol, 1,2,3,4,4a,7,8,8a-octahydro-1,6-dimethyl-4-(1-methylethyl)-, (1S,4S,4aR,8aR)-
Database identifiers
- CAS
5937-11-1- PubChem CID
- 160799
- ChEMBL
CHEMBL2228955- ChEBI
CHEBI:138042- Nikkaji
- J15.462H
Properties
Physicochemical properties
- Melting point
- 139 · 139-140 °C
- Boiling point
- 303.4 · 303.4±31.0 °C(Predicted)
- Density
- 0.937 · 0.937±0.06 g/cm3(Predicted)
- pka
- 15.05 · 15.05±0.60(Predicted)
- Odor
- 100 % · at 100.00 %. pure has no odor but mixtures have balsam earthy
- Odor Type
- balsamic
- LogP
- 4.899 · 4.899 (est)
Chemistry & industry
Applications
UsesT-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC50 values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease[1].
Additional notes
DefinitionChEBI: Tau-cadinol is a cadinane sesquiterpenoid that is cadin-4-ene carrying a hydroxy substituent at position 10. It has a role as a volatile oil component and a plant metabolite. It is a cadinane sesquiterpenoid, a carbobicyclic compound, a tertiary alcohol and a member of octahydronaphthalenes.
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