6-Methyl-2-nitrobenzoic acid

HCID 16097CAS 13506-76-8

Basic information

Standard SMILES
Cc1cccc([N+](=O)[O-])c1C(=O)O
InChIKey
CCXSGQZMYLXTOI-UHFFFAOYSA-N
Molecular formula
C8H7NO4
Average molar mass
181.15 g/mol
Monoisotopic mass
181.0375077

Overview

2-methyl-6-nitrobenzoic acid appears as pale yellow needles or tan powder. (NTP, 1992)

Names & identifiers

Preferred name
6-Methyl-2-nitrobenzoic acid
IUPAC
2-methyl-6-nitrobenzoic acid
English name
2-Methyl-6-nitrobenzoic acid
Molecular formula
C8H7NO4
Molecular weight
181.15

Names & synonyms

2-METHYL-6-NITROBENZOIC ACID13506-76-86-Nitro-o-toluic acid6-Methyl-2-nitrobenzoic acidBenzoic acid, 2-methyl-6-nitro-o-Toluic acid, 6-nitro-DTXSID7025639EINECS 236-833-3JM85Y56DX1DTXCID205639METHYL-6-NITROBENZOIC ACID, 2-RefChem:543836
Show more names
RARECHEM AL BO 0232Methyl-6-nitrobenzoic2-Carboxy-3-nitrotoluene2-Methyl-6-nitrobenzoicAci6-Nitro-2-methylbenzoic acid2-Methyl-6-nitrobenzonic acid
236-833-32-methyl-6-nitro-benzoic acidMFCD000072672-Nitro-6-methylbenzoic acid2-methyl-nitrobenzoic acidMLS002152875SMR0012244902-methyl-6-nitrobenzoicacid

Database identifiers

CAS
13506-76-8
PubChem CID
16097
DTXSID
DTXSID7025639
ChEMBL
CHEMBL1300395
UNII
JM85Y56DX1
EC Number
236-833-3
Nikkaji
J135.795F

Properties

Computed structural properties

XLogP
0.8
Topological polar surface area
83.1 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
4
Rotatable bonds
1
Heavy atoms
13

Experimental & physicochemical properties

Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Melting Point309 to 313 °F (NTP, 1992)
Physical Description2-methyl-6-nitrobenzoic acid appears as pale yellow needles or tan powder. (NTP, 1992)

Physicochemical properties

Melting point
153 · 153-157 °C (lit.)
Boiling point
314.24 °C · 314.24°C (rough estimate)
Density
1.4283 · 1.4283 (rough estimate)
refractive index
1.5468 · 1.5468 (estimate)
storage temp.
Sealed in dry,Room Temperature
solubility
DMSO, Methanol

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 8 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health HazardsExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Reactive GroupAcids, Carboxylic
Reactivity Profile · 1 item

2-METHYL-6-NITROBENZOIC ACID is a nitrated carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.

Air and Water ReactionsInsoluble in water.

Safety & protection

Fire FightingFires involving this chemical can be controlled with a dry chemical, carbon dioxide, or Halon extinguisher. (NTP, 1992)
First Aid · 1 item

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 item

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE) · 1 item

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Safety data

PPE
Eyeshields, Gloves, type N95 (US)
wgk
3
hs_code
29163990
risk_code
36/37/38-20/21/22
Signal word
Warning
Symbol(GHS)
GHS07

Chemistry & industry

Applications

Uses2-Methyl-nitrobenzoic acid acts as herbicide due to the anthranilic acid moiety within the substructure.

General DescriptionPale yellow needles or tan powder.

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
毕佳索(上海毕得医药科技股份有限公司)400-6005915 · [email protected]
苏州启航生物科技有限公司18151111370 · [email protected]

Related reactions

34 records

Linked notes

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