Completing data — usually done within a minute
Basic information
- CAS
2016-88-8- Standard SMILES
NC(N)=NC(=O)c1nc(Cl)c(N)nc1N- InChIKey
XSDQTOBWRPYKKA-UHFFFAOYSA-N- Molecular formula
- C6H8ClN7O
- Average molar mass
- 229.631 g/mol
- Monoisotopic mass
- 229.04788556
Names & identifiers
- Preferred name
- Amiloride
- IUPAC
- 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
- English name
- AMILORIDE
- Molecular formula
- C6H8ClN7O
- Molecular weight
- 229.63
Names & synonyms
MK-870AMILORIDEAMILORIDE ImpurityN-amidino-3,5-diamino-6-chloropyrazine-2-carboxamide3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide3,5-Diamino-6-chloro-N-(diaminomethylene)pyrazinecarboxamide3,5-Diamino-6-chloro-N-(aminoiminomethyl)-2-pyrazinecarboxamide2-Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
Database identifiers
- CAS
2016-88-8、2609-46-3- PubChem CID
- 16231
- DTXSID
DTXSID9043853- ChEMBL
CHEMBL945- ChEBI
CHEBI:2639- UNII
- 7DZO8EB0Z3
- EC Number
- 220-024-7、926-801-3
- Nikkaji
- J9.514A
Properties
Physicochemical properties
- Melting point
- 240.5 · 240.5-241.5°
- Density
- 2.11 · 2.11±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 8.7 · pKa 8.7 (Uncertain)
- form
- Solid
- color
- Off-white to light yellow
- Water Solubility
- 659 g/L · 659g/L(25 ºC)
- CAS DataBase Reference
- 2609 · 2609-46-3(CAS DataBase Reference)
- FDA UNII
- 7 DZO8EB0Z3 · 7DZO8EB0Z3
- ATC code
- 3 DB01 · C03DB01
- Symbol(GHS)
- 6 · GHS06
- Signal word
- Danger
- Hazard statements
- 319 · H319-H300-H315-H412
- Precautionary statements
- 264 · P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P310-P321-P330-P405-P501-P273-P501
- REACH Registrations
- Active
Safety & regulation
Safety data
- Signal word
- Danger
- Symbol(GHS)
- GHS06
- Hazard statements
- H319-H300-H315-H412
- REACH Registrations
- Active
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P310-P321-P330-P405-P501-P273-P501
Chemistry & industry
Applications
DescriptionAmyloride is also a potassium sparing diuretic that exhibits moderate activity. It is not an antagonist of aldosterone. It inhibits reabsorption of sodium ions and reduces excretion of potassium ions.
UsesAmiloride is an epithelial sodium channel blocker.
UsesDiuretic.
UsesAmyloride is rarely used individually—as a rule it is used in combination with thiazides or loop diuretics. It is mainly used in combination with thiazide diuretics for cardiac insufficiency and hypertension, especially in cases where it is necessary to prevent hypokalemia.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers15 total
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
江苏艾康生物医药研发有限公司025-66061636 19370895928 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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