Basic information
- CAS
2043-38-1- Standard SMILES
CC(C)CC1Nc2cc(Cl)c(S(N)(=O)=O)cc2S(=O)(=O)N1- InChIKey
HGBFRHCDYZJRAO-UHFFFAOYSA-N- Molecular formula
- C11H16ClN3O4S2
- Average molar mass
- 353.8 g/mol
- Monoisotopic mass
- 353.027076
Overview
Butizide is a benzothiadiazine.
Names & identifiers
- Preferred name
- Butizide
- IUPAC
- 6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
- English name
- butizide
- Molecular formula
- C11H16ClN3O4S2
- Molecular weight
- 353.85
Names & synonyms
BUTHIAZIDEButizide2043-38-1thiabutazideButizidaisobutylhydrochlorothiazideButizidumW00SSD35VWDTXSID60227136-Chloro-3,4-dihydro-3-isobutyl-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxidehydrochlorbuthiazideRefChem:122151
Show more names
S-3500Su-6187ModenolSaltucin
DTXCID102713218-048-8ButizidButhiazide [USAN]Butizide [INN]Buthiazide-d10(Major)EunephranButizide (INN)
Database identifiers
- CAS
2043-38-1- PubChem CID
- 16274
- DTXSID
DTXSID6022713- ChEMBL
CHEMBL2104197- ChEBI
CHEBI:135492- UNII
- W00SSD35VW
- EC Number
- 218-048-8
Properties
Computed structural properties
- XLogP
- 1.1
- Topological polar surface area
- 135 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 3
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 582
Physicochemical properties
- Melting point
- 214 · 214-217°C
- Boiling point
- 562.7 · 562.7±60.0 °C(Predicted)
- Density
- 1.4221 · 1.4221 (rough estimate)
- refractive index
- 1.61 · 1.6100 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.01 · 9.01±0.40(Predicted)
- color
- White to Yellow
- FDA UNII
- 0 SSD35VW · W00SSD35VW
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS ClassificationNot Classified
Hazard information
Hazard Classes and CategoriesNot Classified
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents that promote the excretion of urine through their effects on kidney function.
Applications
UsesDiuretic and antihypertensive.
Upstream & downstream products
Upstream raw materials
Suppliers22 total
艾吉析科技（上海）有限公司17717235263 · [email protected]
Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
InvivoChem中国13549236410 · [email protected]
南京生利德生物科技有限公司025-57798810 18652991625 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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